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Interactions of dietary phytosterols...

Khojir-Yeganehrad, Behzad.

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Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice./
作者:	Khojir-Yeganehrad, Behzad.
面頁冊數:	103 p.
附註:	Source: Masters Abstracts International, Volume: 44-01, page: 0320.
Contained By:	Masters Abstracts International44-01.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR05309
ISBN:	0494053097

Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice.
Khojir-Yeganehrad, Behzad.

Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice. - 103 p.

Source: Masters Abstracts International, Volume: 44-01, page: 0320.

Thesis (M.Sc.)--University of Manitoba (Canada), 2005.

Phytosterols are chemicals naturally found in vegetable oils, seeds, nuts, and some tree products. It has been shown that plant sterols inhibit cholesterol absorption, thereby lowering plasma total and low-density lipoprotein (LDL) cholesterol levels without significantly altering high-density lipoprotein (HDL) cholesterol or triglycerides (TG). Cholesterol-lowering effects of phytosterols are associated with a significant reduction in atherosclerosis in apo E-knokout (apo E-KO) mice.

ISBN: 0494053097Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice.
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100 1 $a Khojir-Yeganehrad, Behzad. $3 1905204
245 1 0 $a Interactions of dietary phytosterols with lipid-lowering drugs in apolipoprotein E deficient mice.
300 $a 103 p.
500 $a Source: Masters Abstracts International, Volume: 44-01, page: 0320.
502 $a Thesis (M.Sc.)--University of Manitoba (Canada), 2005.
520 $a Phytosterols are chemicals naturally found in vegetable oils, seeds, nuts, and some tree products. It has been shown that plant sterols inhibit cholesterol absorption, thereby lowering plasma total and low-density lipoprotein (LDL) cholesterol levels without significantly altering high-density lipoprotein (HDL) cholesterol or triglycerides (TG). Cholesterol-lowering effects of phytosterols are associated with a significant reduction in atherosclerosis in apo E-knokout (apo E-KO) mice.
520 $a The interactions between phytosterols and non-statin lipid-lowering agents have not been studied. Thus, it was hypothesized that a combination of phytosterols with niacin or fenofibrate will synergistically impact lipoprotein profile and atherogenesis in apolipoprotein E deficient (apo E-KO) mice.
520 $a The results suggest that: First, addition of plant sterols to niacin may beneficially alter plasma lipoprotein profile and consequently affect atherogenesis in apo E-KO mice. Second, addition of phytosterols to fenofibrate did not result in reductions in plasma cholesterol level and atherosclerotic lesion size in apo E-KO mice. Third, a combination of phytosterols plus fenofibrate or niacin do not appear to change the morphology of the liver and kidney tissues. (Abstract shortened by UMI.)
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