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Effects of estradiol on brian stimul...

Ismail, Nafissa.

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Effects of estradiol on brian stimulation reward and energy balance in male rats.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effects of estradiol on brian stimulation reward and energy balance in male rats./
作者:	Ismail, Nafissa.
面頁冊數:	71 p.
附註:	Source: Masters Abstracts International, Volume: 44-01, page: 0572.
Contained By:	Masters Abstracts International44-01.
標題:	Psychology, Physiological. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR04321
ISBN:	0494043210

Effects of estradiol on brian stimulation reward and energy balance in male rats.
Ismail, Nafissa.

Effects of estradiol on brian stimulation reward and energy balance in male rats. - 71 p.

Source: Masters Abstracts International, Volume: 44-01, page: 0572.

Thesis (M.A.)--Concordia University (Canada), 2005.

Like leptin and insulin, estrogen decreases body weight and food intake in male rats; levels of these three hormones vary as a function of fat stores. Thus, it was of interest to determine whether the effect of estrogen on brain stimulation reward (BSR) mimics that of leptin and insulin. The results did not support this prediction: estradiol increased the reward effectiveness of the stimulation in all subjects. The second experiment investigated this relationship by measuring the effect of estradiol implantation on body weight and food intake in ad libitum fed and food restricted male rats. It was found that estrogen further decreased body weight in subjects that had been food-restricted to a level below that of ad libitum fed subjects treated with estrogen. This decrease in body weight is likely due to an increase in energy expenditure. Once ad libitum access to food was restored, the estrogen-treated rats increased their food intake and body weight. This implies that it would be possible to hold constant the weight of food-restricted, estrogen-treated, male rats by adjusting their daily ration. Thus, it should be feasible to investigate the effect of estrogen on BSR in food-restricted male rats whose body weight is held constant. In this way, a direct action of estrogen on the neural substrate for BSR could be distinguished from an indirect influence due to changes in body weight. (Abstract shortened by UMI.)

ISBN: 0494043210Subjects--Topical Terms:

1017869
Psychology, Physiological.

Effects of estradiol on brian stimulation reward and energy balance in male rats.
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520 $a Like leptin and insulin, estrogen decreases body weight and food intake in male rats; levels of these three hormones vary as a function of fat stores. Thus, it was of interest to determine whether the effect of estrogen on brain stimulation reward (BSR) mimics that of leptin and insulin. The results did not support this prediction: estradiol increased the reward effectiveness of the stimulation in all subjects. The second experiment investigated this relationship by measuring the effect of estradiol implantation on body weight and food intake in ad libitum fed and food restricted male rats. It was found that estrogen further decreased body weight in subjects that had been food-restricted to a level below that of ad libitum fed subjects treated with estrogen. This decrease in body weight is likely due to an increase in energy expenditure. Once ad libitum access to food was restored, the estrogen-treated rats increased their food intake and body weight. This implies that it would be possible to hold constant the weight of food-restricted, estrogen-treated, male rats by adjusting their daily ration. Thus, it should be feasible to investigate the effect of estrogen on BSR in food-restricted male rats whose body weight is held constant. In this way, a direct action of estrogen on the neural substrate for BSR could be distinguished from an indirect influence due to changes in body weight. (Abstract shortened by UMI.)
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