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Respiratory rhythm generation: A mo...

Amini, Behrang.

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Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron./
作者:	Amini, Behrang.
面頁冊數:	205 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2977.
Contained By:	Dissertation Abstracts International66-06B.
標題:	Biology, Neuroscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3180665
ISBN:	0542209373

Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron.
Amini, Behrang.

Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron. - 205 p.

Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2977.

Thesis (Ph.D.)--The University of Texas Graduate School of Biomedical Sciences at Houston, 2005.

The respiratory central pattern generator is a collection of medullary neurons that generates the rhythm of respiration. The respiratory central pattern generator feeds phrenic motor neurons, which, in turn, drive the main muscle of respiration, the diaphragm. The purpose of this thesis is to understand the neural control of respiration through mathematical models of the respiratory central pattern generator and phrenic motor neurons.

ISBN: 0542209373Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron.
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245 1 0 $a Respiratory rhythm generation: A modeling study of the respiratory central pattern generator and the phrenic motor neuron.
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500 $a Source: Dissertation Abstracts International, Volume: 66-06, Section: B, page: 2977.
500 $a Supervisor: John H. Byrne.
502 $a Thesis (Ph.D.)--The University of Texas Graduate School of Biomedical Sciences at Houston, 2005.
520 $a The respiratory central pattern generator is a collection of medullary neurons that generates the rhythm of respiration. The respiratory central pattern generator feeds phrenic motor neurons, which, in turn, drive the main muscle of respiration, the diaphragm. The purpose of this thesis is to understand the neural control of respiration through mathematical models of the respiratory central pattern generator and phrenic motor neurons.
520 $a We first designed and validated a Hodgkin-Huxley type model that mimics the behavior of phrenic motor neurons under a wide range of electrical and pharmacological perturbations. This model was constrained physiological data from the literature. Next, we designed and validated a model of the respiratory central pattern generator by connecting four Hodgkin-Huxley type models of medullary respiratory neurons in a mutually inhibitory network. This network was in turn driven by a simple model of an endogenously bursting neuron, which acted as the pacemaker for the respiratory central pattern generator. Finally, the respiratory central pattern generator and phrenic motor neuron models were connected and their interactions studied.
520 $a Our study of the models has provided a number of insights into the behavior of the respiratory central pattern generator and phrenic motor neurons. These include the suggestion of a role for the T-type and N-type calcium channels during single spikes and repetitive firing in phrenic motor neurons, as well as a better understanding of network properties underlying respiratory rhythm generation. We also utilized an existing model of lung mechanics to study the interactions between the respiratory central pattern generator and ventilation.
590 $a School code: 2034.
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