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Design and development of a rupturab...

Talukder, Rahmat M.

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Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon./
作者:	Talukder, Rahmat M.
面頁冊數:	309 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2599.
Contained By:	Dissertation Abstracts International66-05B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176855
ISBN:	0542161583

Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon.
Talukder, Rahmat M.

Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon. - 309 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2599.

Thesis (Ph.D.)--Temple University, 2005.

The objectives of this project encompass the design and development of a drug delivery system for delivering therapeutic agents to the distal parts of the intestine and to the colon for topical and/or systemic effects. The physicochemical properties pertaining to formulation development of the model drug (5-aminosalicylic acid) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active agent to develop an erodable matrix system.

ISBN: 0542161583Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon.
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245 1 0 $a Design and development of a rupturable drug delivery system for delivering drug to the distal gastrointestinal tract-colon.
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500 $a Chair: Reza Fassihi.
502 $a Thesis (Ph.D.)--Temple University, 2005.
520 $a The objectives of this project encompass the design and development of a drug delivery system for delivering therapeutic agents to the distal parts of the intestine and to the colon for topical and/or systemic effects. The physicochemical properties pertaining to formulation development of the model drug (5-aminosalicylic acid) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active agent to develop an erodable matrix system.
520 $a To this end, the fundamental two determinants of gastrointestinal physiology, namely temporal and spatial phenomena have been exploited. In delivery system design, the dry core was subjected to two layers of functional coats. The first or the inner coat was to satisfy the spatial requirements and the outer one was to meet either temporal alone or temporal in conjunction with spatial requirements in order to release the active in the lower parts of the intestine.
520 $a In brief, the system was coated first with a film-forming agent having pH dependent solubility (e.g., cellulose acetate phthalate) and a second coat with a film forming material that was semipermeable (e.g., ethylcellulose) to water and gastric juice alone or in combination with suitable channel forming substances (polyethylene glycol). In vitro evaluation in bio-relevant media exhibited that the tablets started releasing their contents in 3 to 6 hours from the beginning of the dissolution depending on pH environment and the thickness of the coats.
520 $a The controlled onset feature of the designed system has potential to provide (a) release of active agents at specific locations along the gastrointestinal tract or (b) protection of the active agents from the harsh environment of the upper gastrointestinal tract or (c) protection of upper gastrointestinal tract from any damage the active ingredients may cause or (d) the treatment of diseases that occur only in certain regions of gastrointestinal tract or (e) for delivering active agents for topical actions in the gastrointestinal tract or for their systemic absorption.
520 $a Through these steps a novel and improved pharmaceutical composition for delivering active agent(s) from the delivery system with a desired time delay and controlled onset of release was developed and evaluated under simulated GI conditions.
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