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cAMP response element-binding prote...

Brightwell, Jennifer J.

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cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum.

Record Type:	Electronic resources : Monograph/item
Title/Author:	cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum./
Author:	Brightwell, Jennifer J.
Description:	224 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1319.
Contained By:	Dissertation Abstracts International66-03B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3170359
ISBN:	0542065827

cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum.
Brightwell, Jennifer J.

cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum. - 224 p.

Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1319.

Thesis (Ph.D.)--Tulane University, 2005.

The cumulative results of the present experiments show that CREB is essential for long-term memory formation in both the hippocampus and striatum. First, CREB activation was shown to be selective to brain regions specialized for different forms of memory processing. Increased phosphorylated CREB levels were sustained in the hippocampus of rats choosing a hippocampal-dependent place strategy whereas increased phosphorylated CREB levels were sustained in the striatum of rats choosing a striatal-dependent response strategy. Second, basal hippocampal CREB levels were shown to be decreased in a rat model system of hippocampal dysfunction and long-term memory impairment. Third, blocking CREB function in either the hippocampus or striatum suppressed long-term memory formation in a hippocampal- or striatal-dependent task, respectively. Fourth, increasing levels of CREB in the hippocampus facilitated long-term memory in a hippocampal-dependent task. Finally, the results shown here reveal that enhancing or blocking CREB function is only successful in altering memory formation if CREB is manipulated in the brain region that supports the type of memory being measured. Taken together, the results support the hypothesis that the hippocampus and striatum are central structures of two independent memory systems that simultaneously acquire information from the environment. The behavior that is produced is mediated by the brain system most congruent with the incoming stimuli.

ISBN: 0542065827Subjects--Topical Terms:

1017680
Biology, Neuroscience.

cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum.
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100 1 $a Brightwell, Jennifer J. $3 1905088
245 1 0 $a cAMP response element-binding protein is essential for long-term memory formation in the hippocampus and striatum.
300 $a 224 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-03, Section: B, page: 1319.
500 $a Adviser: Paul J. Colombo.
502 $a Thesis (Ph.D.)--Tulane University, 2005.
520 $a The cumulative results of the present experiments show that CREB is essential for long-term memory formation in both the hippocampus and striatum. First, CREB activation was shown to be selective to brain regions specialized for different forms of memory processing. Increased phosphorylated CREB levels were sustained in the hippocampus of rats choosing a hippocampal-dependent place strategy whereas increased phosphorylated CREB levels were sustained in the striatum of rats choosing a striatal-dependent response strategy. Second, basal hippocampal CREB levels were shown to be decreased in a rat model system of hippocampal dysfunction and long-term memory impairment. Third, blocking CREB function in either the hippocampus or striatum suppressed long-term memory formation in a hippocampal- or striatal-dependent task, respectively. Fourth, increasing levels of CREB in the hippocampus facilitated long-term memory in a hippocampal-dependent task. Finally, the results shown here reveal that enhancing or blocking CREB function is only successful in altering memory formation if CREB is manipulated in the brain region that supports the type of memory being measured. Taken together, the results support the hypothesis that the hippocampus and striatum are central structures of two independent memory systems that simultaneously acquire information from the environment. The behavior that is produced is mediated by the brain system most congruent with the incoming stimuli.
590 $a School code: 0235.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Psychobiology. $3 1017821
650 4 $a Psychology, Physiological. $3 1017869
690 $a 0317
690 $a 0349
690 $a 0989
710 2 0 $a Tulane University. $3 1019475
773 0 $t Dissertation Abstracts International $g 66-03B.
790 1 0 $a Colombo, Paul J., $e advisor
790 $a 0235
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3170359