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Effects of excitotoxic lesions withi...

Hale, Amy Elizabeth.

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Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat./
Author:	Hale, Amy Elizabeth.
Description:	201 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0608.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Psychology, Physiological. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159738
ISBN:	0496928589

Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat.
Hale, Amy Elizabeth.

Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat. - 201 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0608.

Thesis (Ph.D.)--Columbia University, 2005.

The present dissertation (1) examines the concept of working memory and proactive interference, (2) critically examines past research investigating the role of the rodent prefrontal cortex in working memory paradigms, and (3) presents the results of four experiments designed to investigate the effects of differential prefrontal lesions on spatial working memory, proactive interference, and a conditioned response task. The first two experiments examined the delay dependent impairment in a spatial working memory task in rats and tested the hypothesis that lesions of the medial prefrontal cortex produce behavioral and anatomically-specific working memory deficits. The third experiment investigated the specific phenomenon of proactive interference and the potential role the medial and lateral prefrontal cortices may play in mediating the effects of proactive interference, specifically with regard to working memory function. The last experiment utilized a conditioned approach response paradigm to assess the role of the medial prefrontal cortex in general learning functions as well as possible lesion-induced motor and motivational impairments. The results of these studies provide evidence that the rodent medial but not lateral prefrontal cortex is importantly involved in working memory function, and appears to play a protective role against the impairing effects of proactive interference, with a suggestion of possible behavioral dissociations between medial prefrontal subregions.

ISBN: 0496928589Subjects--Topical Terms:

1017869
Psychology, Physiological.

Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat.
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035 $a (UnM)AAI3159738
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100 1 $a Hale, Amy Elizabeth. $3 1905063
245 1 0 $a Effects of excitotoxic lesions within prefrontal cortical regions on working memory function in the rat.
300 $a 201 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0608.
500 $a Adviser: Jon C. Horvitz.
502 $a Thesis (Ph.D.)--Columbia University, 2005.
520 $a The present dissertation (1) examines the concept of working memory and proactive interference, (2) critically examines past research investigating the role of the rodent prefrontal cortex in working memory paradigms, and (3) presents the results of four experiments designed to investigate the effects of differential prefrontal lesions on spatial working memory, proactive interference, and a conditioned response task. The first two experiments examined the delay dependent impairment in a spatial working memory task in rats and tested the hypothesis that lesions of the medial prefrontal cortex produce behavioral and anatomically-specific working memory deficits. The third experiment investigated the specific phenomenon of proactive interference and the potential role the medial and lateral prefrontal cortices may play in mediating the effects of proactive interference, specifically with regard to working memory function. The last experiment utilized a conditioned approach response paradigm to assess the role of the medial prefrontal cortex in general learning functions as well as possible lesion-induced motor and motivational impairments. The results of these studies provide evidence that the rodent medial but not lateral prefrontal cortex is importantly involved in working memory function, and appears to play a protective role against the impairing effects of proactive interference, with a suggestion of possible behavioral dissociations between medial prefrontal subregions.
590 $a School code: 0054.
650 4 $a Psychology, Physiological. $3 1017869
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Experimental. $3 517106
690 $a 0989
690 $a 0317
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710 2 0 $a Columbia University. $3 571054
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Horvitz, Jon C., $e advisor
790 $a 0054
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3159738