東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Applications of liposomes on anti-ca...

Ran, Yingqing.

FindBook

Google Book

Amazon

博客來

Applications of liposomes on anti-cancer agents.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Applications of liposomes on anti-cancer agents./
作者:	Ran, Yingqing.
面頁冊數:	97 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1878.
Contained By:	Dissertation Abstracts International65-04B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131632
ISBN:	0496788736

Applications of liposomes on anti-cancer agents.
Ran, Yingqing.

Applications of liposomes on anti-cancer agents. - 97 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1878.

Thesis (Ph.D.)--The University of Arizona, 2004.

Toxicity is a major limitation in clinical use of most anticancer drugs. Liposomes, especially targeted long-circulating liposomes, provide the possibility of delivering drugs specifically to targeted cancer tissues, thus increasing anticancer activity and minimizing toxicity.

ISBN: 0496788736Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Applications of liposomes on anti-cancer agents.
LDR:02914nmm 2200313 4500 001 1815614
005 20060710080741.5
008 130610s2004 eng d
020 $a 0496788736
035 $a (UnM)AAI3131632
035 $a AAI3131632
040 $a UnM $c UnM
100 1 $a Ran, Yingqing. $3 1905030
245 1 0 $a Applications of liposomes on anti-cancer agents.
300 $a 97 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1878.
500 $a Director: Samuel H. Yalkowsky.
502 $a Thesis (Ph.D.)--The University of Arizona, 2004.
520 $a Toxicity is a major limitation in clinical use of most anticancer drugs. Liposomes, especially targeted long-circulating liposomes, provide the possibility of delivering drugs specifically to targeted cancer tissues, thus increasing anticancer activity and minimizing toxicity.
520 $a 2-4'-Amino-3'-methylphenylbenzothiazole (AMPB), a potent anticancer drug, is inappropriate for traditional oral or parenteral formulations because of its severe dose-limiting hepatotoxicity. Several PEG-coated liposomal formulations were developed by using different drug/lipid ratios. Particle size and encapsulation efficiency of each formulation were investigated; the most stable liposomal formulation was selected for animal testing. The formulation with AMPB/egg phosphatidyl choline/cholesterol/1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-polyethylene glycol 2000, PEG2000-DSPE in a 1/5/5/1 molar ratio is the best formulation. This formulation contains 2 mg/ml AMPB with encapsulation efficiency above 95%, average particle size 120--150 nm.
520 $a Daunorubicin is a well known anti cancer agent. To minimize its cardiotoxicity, targeted folate-PEG-liposomes were developed in this study. The pH-gradient loading method was used to increase the drug loading efficiency. Above 97% loading efficiency was reached by creating a 3 to 4 unit pH difference across the liposome membrane. The final folate-PEG-liposomml formulation contained 2.5 mg/ml daunorubicin HCI, with average particle size of 110&sim;120 nm, pH of &sim;7.4, and a drug/lipid ratio 1/20 (w/w).
520 $a The solvent, chloroform, commonly used for liposome preparation, is harmful to humans. Therefore, halothane, a commonly used inhalation anesthetic, was used in this study in place of chloroform to prepare liposomes. AMPB and several other proprietary anticancer agents were formulated in liposomes by using halothane and chloroform. No obvious differences in physicochemical properties were observed between halothane and chloroform mediated liposomes.
590 $a School code: 0009.
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0491
690 $a 0572
710 2 0 $a The University of Arizona. $3 1017508
773 0 $t Dissertation Abstracts International $g 65-04B.
790 1 0 $a Yalkowsky, Samuel H., $e advisor
790 $a 0009
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131632