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Regulation of reverse cholesterol tr...

Hatahet, Wael.

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Regulation of reverse cholesterol transport pathway by fatty acids.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Regulation of reverse cholesterol transport pathway by fatty acids./
作者:	Hatahet, Wael.
面頁冊數:	130 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1787.
Contained By:	Dissertation Abstracts International65-04B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3130344
ISBN:	0496775936

Regulation of reverse cholesterol transport pathway by fatty acids.
Hatahet, Wael.

Regulation of reverse cholesterol transport pathway by fatty acids. - 130 p.

Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1787.

Thesis (Ph.D.)--Wayne State University, 2004.

Reverse cholesterol transport (RCT): is one pathway for removing excessive cholesterol from extrahepatic tissues and the eventual transport to the liver for excretion, thus reducing accumulation of cholesterol in arteries. Since HDL is the major carrier of cellular cholesterol throughout RCT, it makes sense to believe that HDL levels are detrimental in the assessment of RCT activity. The important role that LCAT plays in HDL metabolism has been established in both patients and animals with LCAT deficiency, as well as in animals over expressing human LCAT. It was previously reported, that fatty acids modulate the expression of LCAT and apolipoprotein A-I, two major components of HDL involved in RCT (Fungwe et al., 1998). The purpose of the present study was to examine whether the observations made in vitro in primary rat hepatocytes, also occurred in vivo, in rats fed dietary fats enriched with the same fatty acids, and in more humanized model that was genetically altered to incorporate enzymes that are usually missing in RCT pathway in mice.

ISBN: 0496775936Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Regulation of reverse cholesterol transport pathway by fatty acids.
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245 1 0 $a Regulation of reverse cholesterol transport pathway by fatty acids.
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500 $a Source: Dissertation Abstracts International, Volume: 65-04, Section: B, page: 1787.
500 $a Adviser: Thomas V. Fungwe.
502 $a Thesis (Ph.D.)--Wayne State University, 2004.
520 $a Reverse cholesterol transport (RCT): is one pathway for removing excessive cholesterol from extrahepatic tissues and the eventual transport to the liver for excretion, thus reducing accumulation of cholesterol in arteries. Since HDL is the major carrier of cellular cholesterol throughout RCT, it makes sense to believe that HDL levels are detrimental in the assessment of RCT activity. The important role that LCAT plays in HDL metabolism has been established in both patients and animals with LCAT deficiency, as well as in animals over expressing human LCAT. It was previously reported, that fatty acids modulate the expression of LCAT and apolipoprotein A-I, two major components of HDL involved in RCT (Fungwe et al., 1998). The purpose of the present study was to examine whether the observations made in vitro in primary rat hepatocytes, also occurred in vivo, in rats fed dietary fats enriched with the same fatty acids, and in more humanized model that was genetically altered to incorporate enzymes that are usually missing in RCT pathway in mice.
520 $a The data from the rat study suggest that dietary triolein positively impacted the metabolism of plasma HDL compared to tripalmitin or menhaden oil. Accordingly, triolein significantly increased the expression of components essential to metabolism of HDL and RCT, while the data from the transgenic mouse study confirmed the previous observation. In addition, the above findings make it possible to be speculated that the level of TG induced by this fatty acid may play a role in the uptake or turnover rates of HDL. However, it again demonstrates why FAs should be investigated individually rather than as groups of fatty acid classes.
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