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Heterochromatin in developing system...

Stankiewicz, Rebecca Leigh.

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Heterochromatin in developing systems: The role of the Y chromosome in sperm development in Drosophila melanogaster.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Heterochromatin in developing systems: The role of the Y chromosome in sperm development in Drosophila melanogaster./
作者:	Stankiewicz, Rebecca Leigh.
面頁冊數:	167 p.
附註:	Source: Dissertation Abstracts International, Volume: 61-08, Section: B, page: 3979.
Contained By:	Dissertation Abstracts International61-08B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9984089
ISBN:	0599910836

Heterochromatin in developing systems: The role of the Y chromosome in sperm development in Drosophila melanogaster.
Stankiewicz, Rebecca Leigh.

Heterochromatin in developing systems: The role of the Y chromosome in sperm development in Drosophila melanogaster. - 167 p.

Source: Dissertation Abstracts International, Volume: 61-08, Section: B, page: 3979.

Thesis (Ph.D.)--University of Connecticut, 2000.

The Y chromosome of Drosophila melanogaster has two types of loci. The first type of locus consists of single copy genes known as fertility factors. These are required only for sperm development. A P element mutagenesis screen was conducted to locate these factors. TEM reveals that P elements inserted into fertility factors give the same ultra structure phenotypes as deficiencies of the region. In addition, two new Y chromosome lines were isolated that have enhancer trap expression in testes. The second type of locus is repetitive. I conducted a screen of heterochromatic elements on the Y chromosome. This screen revealed repetitive loci that act as developmental modifiers. This was investigated using fusion proteins inserted in P elements. This study revealed that these repetitive loci are not unique to the Y chromosome and act in both the germline and soma as developmental buffers. The repetitive loci act to modulate the expression of genes. Manipulations of the Y chromosome to alter the amount of the repetitive loci present in a given fly suggest that when the balance of these repetitive loci is disturbed, developmental instability results. Investigations of loci on the Y, X and autosomes in different backgrounds suggests that there is substantially more variation in these elements in the X and autosomes than the Y. This is consistent with the selective sweep hypothesis of Drosophila Y chromosome evolution.

ISBN: 0599910836Subjects--Topical Terms:

1017730
Biology, Genetics.

Heterochromatin in developing systems: The role of the Y chromosome in sperm development in Drosophila melanogaster.
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500 $a Adviser: Hallie Krider.
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520 $a The Y chromosome of Drosophila melanogaster has two types of loci. The first type of locus consists of single copy genes known as fertility factors. These are required only for sperm development. A P element mutagenesis screen was conducted to locate these factors. TEM reveals that P elements inserted into fertility factors give the same ultra structure phenotypes as deficiencies of the region. In addition, two new Y chromosome lines were isolated that have enhancer trap expression in testes. The second type of locus is repetitive. I conducted a screen of heterochromatic elements on the Y chromosome. This screen revealed repetitive loci that act as developmental modifiers. This was investigated using fusion proteins inserted in P elements. This study revealed that these repetitive loci are not unique to the Y chromosome and act in both the germline and soma as developmental buffers. The repetitive loci act to modulate the expression of genes. Manipulations of the Y chromosome to alter the amount of the repetitive loci present in a given fly suggest that when the balance of these repetitive loci is disturbed, developmental instability results. Investigations of loci on the Y, X and autosomes in different backgrounds suggests that there is substantially more variation in these elements in the X and autosomes than the Y. This is consistent with the selective sweep hypothesis of Drosophila Y chromosome evolution.
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