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Stable polymer micelle systems as an...

Zeng, Yi.

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Stable polymer micelle systems as anti-cancer drug delivery carriers.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Stable polymer micelle systems as anti-cancer drug delivery carriers./
作者:	Zeng, Yi.
面頁冊數:	124 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2538.
Contained By:	Dissertation Abstracts International66-05B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3173741
ISBN:	0542110970

Stable polymer micelle systems as anti-cancer drug delivery carriers.
Zeng, Yi.

Stable polymer micelle systems as anti-cancer drug delivery carriers. - 124 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2538.

Thesis (Ph.D.)--Brigham Young University, 2005.

Several temporarily stable polymer micelle systems that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were PlurogelRTM, Tetronic RTM, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactate n).

ISBN: 0542110970Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Stable polymer micelle systems as anti-cancer drug delivery carriers.
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245 1 0 $a Stable polymer micelle systems as anti-cancer drug delivery carriers.
300 $a 124 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2538.
500 $a Adviser: William G. Pitt.
502 $a Thesis (Ph.D.)--Brigham Young University, 2005.
520 $a Several temporarily stable polymer micelle systems that might be used as ultrasonic-activated drug delivery carriers were synthesized and investigated. These polymeric micelle systems were PlurogelRTM, Tetronic RTM, poly(ethylene oxide)-b-poly(N-isopropylacrylamide) and poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactate n).
520 $a In previous work in our lab, Pruitt et al. developed a stabilized drug carrier named PlurogelRTM [5, 6]. Unfortunately, the rate of the successful PlurogelRTM synthesis was only about 30% by simply following Pruitt's process. In this work, this rate was improved to 60% by combining the process of adding 0.15 M NaCl and/or 10 mul/ml n-butanol and by preheating the solution before polymerization.
520 $a TetronicsRTM were proved not to be good candidates to form temporarily stable polymeric micelle system by polymerizing interpenetrating networks inside their micelle cores. Tetronic micelle systems treated by this process still were not stable at concentrations below their critical micelle concentration (CMC).
520 $a Poly(ethylene oxide)-b-poly(N-isopropylacrylamide)-N,N-bis(acryloyl)cystamine micelle-like nanoparticles were developed and characterized. When the N,N-bis(acryloyl)cystamine (BAC) was from 0.2 wt% to 0.75 wt% of the mass of poly(N-isopropylacrylamide), diameters of the nanoparticles at 40°C were less than 150 nm. The cores of the nanoparticles were hydrophobic enough to sequester 1,6-diphenylhexatriene (DPH) and the anti-cancer drug doxorubicin (DOX). Nanoparticles with 0.5 wt% BAC stored at room temperature in 0.002 mg/ml solutions were stable for up to two weeks.
520 $a Poly(ethylene oxide)-b-poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate-lactate n) micelle systems were synthesized and characterized. The degree of polymerization of lactate side group, n, was 3 or 5. The copolymers with N-isopropylacrylamide:2-hydroxyethyl methacrylate-lactate3: poly(ethylene oxide) (NIPAAm:HEMA-lactate 3:PEO) ratios of 20.0:5.0:1 or 22.5:2.5:1 and with NIPAAm:HEMA-lactate 5:PEO ratios of 17.5:7.5:1, 20.0:5.0:1 or 22.5:2.5:1 produced micelles stable about 2 days at 40°C. The cores of the micelles were hydrophobic enough to sequester DPH and DOX. The DOX release from the micelles having molar ratio of NIPAAm:HEMA-lactate3:PEO equal to 20.0:5.0:1 was about 2% at room temperature and 4% at body temperature. This system is a possible candidate for ultrasonically activated drug delivery.
590 $a School code: 0022.
650 4 $a Health Sciences, Pharmacy. $3 1017737
650 4 $a Engineering, Chemical. $3 1018531
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650 4 $a Health Sciences, Oncology. $3 1018566
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710 2 0 $a Brigham Young University. $3 1017451
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790 1 0 $a Pitt, William G., $e advisor
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791 $a Ph.D.
792 $a 2005
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