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Modulation of bovine immune response...

Maue, Alexander C.

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Modulation of bovine immune responses to genetic immunization.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Modulation of bovine immune responses to genetic immunization./
作者:	Maue, Alexander C.
面頁冊數:	158 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-09, Section: B, page: 4713.
Contained By:	Dissertation Abstracts International66-09B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3189940
ISBN:	054233710X

Modulation of bovine immune responses to genetic immunization.
Maue, Alexander C.

Modulation of bovine immune responses to genetic immunization. - 158 p.

Source: Dissertation Abstracts International, Volume: 66-09, Section: B, page: 4713.

Thesis (Ph.D.)--University of Missouri - Columbia, 2005.

Genetic immunization elicits robust humoral and cell-mediated immune responses to encoded antigen. It has been difficult to generate comparable responses in non-rodent species. Three independent trials were conducted in cattle to determine the adjuvant effects of plasmid-encoded CD80/CD86 or CD154 co-administered with CpG ODN, and granulocyte macrophage-colony stimulating factor on DNA vaccines (ESAT-6 and ESAT-6:CFP10) against bovine tuberculosis. Co-administration of CD80/CD86 or CD154 enhanced antigen-specific IFN-gamma responses to ESAT-6 compared to control vaccinates. Following aerosol challenge with Mycobacterium bovis, only animals vaccinated with CD80/CD86 possessed decreased pathology of the lungs and associated lymph nodes. Immunization with an ESAT-6:CFP10 + GM-CSF + CD80/CD86 DNA vaccine resulted in enhanced proliferative responses and IFN-gamma production. Efficacy of the ESAT-6:CFP10 + GM-CSF + CD80/CD86 DNA vaccine was not evaluated. Collectively, these results demonstrate that bovine immune responses to genetic immunization can be enhanced following co-administration of molecular adjuvants.

ISBN: 054233710XSubjects--Topical Terms:

1017716
Health Sciences, Immunology.

Modulation of bovine immune responses to genetic immunization.
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