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The biomechanics of the mitral valve.

Chen, Ling.

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The biomechanics of the mitral valve.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The biomechanics of the mitral valve./
作者:	Chen, Ling.
面頁冊數:	235 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2148.
Contained By:	Dissertation Abstracts International66-04B.
標題:	Applied Mechanics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3171108
ISBN:	0542077930

The biomechanics of the mitral valve.
Chen, Ling.

The biomechanics of the mitral valve. - 235 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2148.

Thesis (Ph.D.)--University of California, San Diego and San Diego State University, 2005.

The mitral valve is a delicate membrane structure inside the heart that prevents backflow of blood from the left ventricular chamber as the heart contracts. Patients worldwide experience mitral valve problems, which often lead to traumatic and sometimes recurrent surgeries. Current surgical innovations are often driven by physician experience and commercial considerations rather than quantitative basic science.

ISBN: 0542077930Subjects--Topical Terms:

1018410
Applied Mechanics.

The biomechanics of the mitral valve.
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100 1 $a Chen, Ling. $3 1619256
245 1 4 $a The biomechanics of the mitral valve.
300 $a 235 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 2148.
500 $a Chairs: Karen May-Newman; David Benson.
502 $a Thesis (Ph.D.)--University of California, San Diego and San Diego State University, 2005.
520 $a The mitral valve is a delicate membrane structure inside the heart that prevents backflow of blood from the left ventricular chamber as the heart contracts. Patients worldwide experience mitral valve problems, which often lead to traumatic and sometimes recurrent surgeries. Current surgical innovations are often driven by physician experience and commercial considerations rather than quantitative basic science.
520 $a Describing the motion, stress and deformation of structures in the body is critical to understanding their function and to focusing development of surgical treatments and medical prosthetics. Engineering models of biomechanics and physiology yield quantitative information for the understanding of normal and disease processes as well as the development of novel treatment methodologies. Towards this end, a finite element model of the mitral valve is proposed, which will capture the complex geometry, material properties and boundary conditions and assess the function of this structure in health and disease.
520 $a MRI is a non-invasive imaging modality that has been an important source of anatomical and functional information providing high-resolution three-dimensional spatial data and soft tissue contrast. MRI imaging of isolated porcine heart was performed to reconstruct the complex 3D geometry of the mitral valve. The anatomical data collected from serial MR images were imported into Continuity, a finite element analysis program. These data were fitted to render finite element model.
520 $a A constitutive law for the mitral valve tissue was implemented in the FE environment, Continuity. A user subroutine was developed to interface with the software. The correctness of the constitutive model implementation was verified by reproducing the biaxial experimental results accurately. Material anisotropy, which is closely associated with local microstructural architecture, was simulated by incorporating regional variations in collagen fiber orientation. Physiological realistic loading boundary conditions were applied to the model.
520 $a Experimental measurements of the leaflet deformation under pressure loading were performed on in situ isolated pig hearts for model validation and refinement. This data provides an essential check on the model predictions. By improving the agreement between the model outputs and the experimental data, the computational model was validated. In addition, the effect of strut chordae transaction (SCT) on the leaflet biomechanics was investigated both experimentally and computationally.
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650 4 $a Applied Mechanics. $3 1018410
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790 1 0 $a May-Newman, Karen, $e advisor
790 1 0 $a Benson, David, $e advisor
790 $a 0385
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3171108