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Microstructural mechanics of collage...

Chandran, Preethi Lourdes.

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Microstructural mechanics of collagen gels and tissue equivalents.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Microstructural mechanics of collagen gels and tissue equivalents./
作者:	Chandran, Preethi Lourdes.
面頁冊數:	198 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6496.
Contained By:	Dissertation Abstracts International65-12B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3156772
ISBN:	0496174630

Microstructural mechanics of collagen gels and tissue equivalents.
Chandran, Preethi Lourdes.

Microstructural mechanics of collagen gels and tissue equivalents. - 198 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6496.

Thesis (Ph.D.)--University of Minnesota, 2005.

This aim of this study was to correlate the macro-scale mechanics of a collagen gel to the kinematics at the microstructural level, and formulate a mathematical model that addressed both.

ISBN: 0496174630Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Microstructural mechanics of collagen gels and tissue equivalents.
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100 1 $a Chandran, Preethi Lourdes. $3 1904069
245 1 0 $a Microstructural mechanics of collagen gels and tissue equivalents.
300 $a 198 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6496.
500 $a Adviser: Victor Howard Barocas.
502 $a Thesis (Ph.D.)--University of Minnesota, 2005.
520 $a This aim of this study was to correlate the macro-scale mechanics of a collagen gel to the kinematics at the microstructural level, and formulate a mathematical model that addressed both.
520 $a Collagen gels, reconstituted in-vitro from type-1 collagen, are a useful model of tissue mechanics. The gel is comprised solely of collagen fibrils, a major mechanical component of soft tissues, and retains a large part of the in-vivo physiological character. Under the microscope, the gel appears a hydrated mesh of nearly straight fibrils. Confined compression experiments performed with simultaneous birefringence imaging suggested the fibrils to be interconnected. The bending of fibers (relative angle change) at interconnections and retardation by viscous drag was found responsible for the mechanics observed at the macro-scale. A network model of collagen gel mechanics was proposed.
520 $a Traditional models of fibrous tissue neglect load transfer between fibrils (as occurs in a network) and approximate the kinematics of the independently-deforming fiber to be affine with the matrix. A simulation study was performed on a microstructure based on the collagen gel, and it was concluded that the computationally-attractive affine assumption could not capture network behavior.
520 $a A multi-scale model of collagen-gel mechanics was proposed to the enable the study of macro-scale boundary value problems but with constitutive response determined at the micro-scale network level. The model was derived from ideas of Averaging theory and solved at the macro-scale using Finite Elements, and analyzed at the micro-scale using Representative Volume Elements. The mono-phasic model was able to predict key observations in a published study of tissue equivalents in uniaxial extension. A simplified wound mechanics problem was also simulated.
520 $a To simulate gel behavior in confined compression, a biphasic version of the network model was derived. A microstructural representation of an elastic network, with elastic bending resistance, and retarded by a Stokes-like viscous drag was able to reproduce the behavior observed in the experimental study.
520 $a This work contributes to the analysis of tissues where fibril-fibril load transfer is important. The insight into collagen gel micro-mechanics is a step towards deciphering the complex relation between microstructure and mechanical properties in real tissues.
590 $a School code: 0130.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Applied Mechanics. $3 1018410
650 4 $a Engineering, Materials Science. $3 1017759
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690 $a 0346
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710 2 0 $a University of Minnesota. $3 676231
773 0 $t Dissertation Abstracts International $g 65-12B.
790 1 0 $a Barocas, Victor Howard, $e advisor
790 $a 0130
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3156772