東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The influence of environmental toxin...

McCrae, Kimberly C.

Linked to FindBook

Google Book

Amazon

博客來

The influence of environmental toxins on the pulmonary system.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The influence of environmental toxins on the pulmonary system./
Author:	McCrae, Kimberly C.
Description:	218 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6271.
Contained By:	Dissertation Abstracts International65-12B.
Subject:	Health Sciences, Dentistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ97290
ISBN:	0612972909

The influence of environmental toxins on the pulmonary system.
McCrae, Kimberly C.

The influence of environmental toxins on the pulmonary system. - 218 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6271.

Thesis (Ph.D.)--University of Manitoba (Canada), 2005.

The lungs are composed of an architectural framework, conducting airways, and alveolar sacs. To prevent collapse of lung tissue, alveolar type II (AT II) cells produce pulmonary surfactant (PS), an amphipathic material composed mostly of saturated phospholipids and cholesterol that lines the air/water interface. Alterations to lung cells (neoplastic transformation) or the PS system (composition and function) may result in respiratory complications. We studied the biochemical composition of urethane-induced AT II neoplasms, the role of cholesterol in PS function, and the effect of exposure to pulmonary toxins produced by the mold S. chartarum. To assess biochemical alterations of neoplastic mouse lung and excised human lung neoplasms, we used a novel technique called Fourier-transform infrared spectroscopy (FTIR), which provides information based on absorption patterns of molecules. Results showed unique biochemistry of mouse neoplasms compared to normal mouse lung. Analyses of human lung lesions revealed also unique but subtle biochemical differences between neoplasms. To study PS function we used capillary surfactometry (CS), which analyzes the ability of a surface-active material to ensure free airflow, thus simulating the small airways. Results demonstrated that excess cholesterol within PS obtained from healthy and tumor-bearing hypercholesterolemic mice had diminished ability to maintain free airflow. Finally, FTIR analyses of PS from mice exposed to S. chartarum spores demonstrated alterations to PS phospholipids. S. chartarum's epigenetic properties were revealed by through analyses of lung fibroblast DNA fragmentation. Alterations to DNA biochemistry, excess PS cholesterol, and epigenetic properties of S. chartarum spore toxins may contribute to the development of reversible and/or irreversible respiratory disorders and diseases.

ISBN: 0612972909Subjects--Topical Terms:

1019378
Health Sciences, Dentistry.

The influence of environmental toxins on the pulmonary system.
LDR:02752nmm 2200277 4500 001 1812383
005 20060424072432.5
008 130610s2005 eng d
020 $a 0612972909
035 $a (UnM)AAINQ97290
035 $a AAINQ97290
040 $a UnM $c UnM
100 1 $a McCrae, Kimberly C. $3 1901930
245 1 4 $a The influence of environmental toxins on the pulmonary system.
300 $a 218 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6271.
500 $a Adviser: J. Elliott Scott.
502 $a Thesis (Ph.D.)--University of Manitoba (Canada), 2005.
520 $a The lungs are composed of an architectural framework, conducting airways, and alveolar sacs. To prevent collapse of lung tissue, alveolar type II (AT II) cells produce pulmonary surfactant (PS), an amphipathic material composed mostly of saturated phospholipids and cholesterol that lines the air/water interface. Alterations to lung cells (neoplastic transformation) or the PS system (composition and function) may result in respiratory complications. We studied the biochemical composition of urethane-induced AT II neoplasms, the role of cholesterol in PS function, and the effect of exposure to pulmonary toxins produced by the mold S. chartarum. To assess biochemical alterations of neoplastic mouse lung and excised human lung neoplasms, we used a novel technique called Fourier-transform infrared spectroscopy (FTIR), which provides information based on absorption patterns of molecules. Results showed unique biochemistry of mouse neoplasms compared to normal mouse lung. Analyses of human lung lesions revealed also unique but subtle biochemical differences between neoplasms. To study PS function we used capillary surfactometry (CS), which analyzes the ability of a surface-active material to ensure free airflow, thus simulating the small airways. Results demonstrated that excess cholesterol within PS obtained from healthy and tumor-bearing hypercholesterolemic mice had diminished ability to maintain free airflow. Finally, FTIR analyses of PS from mice exposed to S. chartarum spores demonstrated alterations to PS phospholipids. S. chartarum's epigenetic properties were revealed by through analyses of lung fibroblast DNA fragmentation. Alterations to DNA biochemistry, excess PS cholesterol, and epigenetic properties of S. chartarum spore toxins may contribute to the development of reversible and/or irreversible respiratory disorders and diseases.
590 $a School code: 0303.
650 4 $a Health Sciences, Dentistry. $3 1019378
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0567
690 $a 0410
710 2 0 $a University of Manitoba (Canada). $3 1018707
773 0 $t Dissertation Abstracts International $g 65-12B.
790 1 0 $a Scott, J. Elliott, $e advisor
790 $a 0303
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NQ97290