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The roles of the homeobox gene Bozoz...

Lee, Kimberly Fekany.

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The roles of the homeobox gene Bozozok in zebrafish axis formation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The roles of the homeobox gene Bozozok in zebrafish axis formation./
作者:	Lee, Kimberly Fekany.
面頁冊數:	150 p.
附註:	Source: Dissertation Abstracts International, Volume: 61-11, Section: B, page: 5688.
Contained By:	Dissertation Abstracts International61-11B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9996207
ISBN:	0493042423

The roles of the homeobox gene Bozozok in zebrafish axis formation.
Lee, Kimberly Fekany.

The roles of the homeobox gene Bozozok in zebrafish axis formation. - 150 p.

Source: Dissertation Abstracts International, Volume: 61-11, Section: B, page: 5688.

Thesis (Ph.D.)--Vanderbilt University, 2000.

The studies described in this Ph.D. dissertation demonstrate the many roles that the zebrafish <italic>bozozok</italic> (<italic>boz</italic>) locus plays in organizer induction and axis formation in zebrafish. The <italic> boz<super>m168</super></italic> mutation was isolated in a large-scale chemical (<italic>N</italic>-ethyl <italic>N</italic>-nitrosourea) mutagenesis screen for mutations that affect early development in zebrafish. <italic>boz</italic> is a recessive, zygotic, embryonic lethal mutation. At one day post fertilization (dpf) <italic>boz<super>m168/m168</super></italic> mutants exhibit a reduction or loss of the main organizer derivatives, notochord and prechordal plate, as well as deficiencies in anterior and ventral CNS structures, suggesting a key role for this gene in axis formation.

ISBN: 0493042423Subjects--Topical Terms:

1017730
Biology, Genetics.

The roles of the homeobox gene Bozozok in zebrafish axis formation.
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245 1 0 $a The roles of the homeobox gene Bozozok in zebrafish axis formation.
300 $a 150 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-11, Section: B, page: 5688.
500 $a Director: Lilianna Solnica-Krezel.
502 $a Thesis (Ph.D.)--Vanderbilt University, 2000.
520 $a The studies described in this Ph.D. dissertation demonstrate the many roles that the zebrafish <italic>bozozok</italic> (<italic>boz</italic>) locus plays in organizer induction and axis formation in zebrafish. The <italic> boz<super>m168</super></italic> mutation was isolated in a large-scale chemical (<italic>N</italic>-ethyl <italic>N</italic>-nitrosourea) mutagenesis screen for mutations that affect early development in zebrafish. <italic>boz</italic> is a recessive, zygotic, embryonic lethal mutation. At one day post fertilization (dpf) <italic>boz<super>m168/m168</super></italic> mutants exhibit a reduction or loss of the main organizer derivatives, notochord and prechordal plate, as well as deficiencies in anterior and ventral CNS structures, suggesting a key role for this gene in axis formation.
520 $a Epistatic analyses demonstrated <italic>boz</italic> acts downstream or in parallel to β-catenin and upstream or in parallel to Nodal signaling. Furthermore, <italic>boz</italic> was found to encode the homeodomain protein Dharma, which was isolated in a screen for factors with axis-inducing potential. Gene expression analyses and fate-mapping studies indicate that <italic>boz </italic> embryos exhibit reduced neural induction and that anterior neural fates are transformed to more posterior ones. Inhibition of Bmp signaling was able to suppress the neural induction defect, but not the AP patterning defect in <italic>boz</italic> mutants. In contrast, inhibition of Wnt signaling was able to suppress both the reduced neural induction and excess posteriorization in <italic>boz</italic> embryos. Therefore, these analyses indicated <italic> boz</italic> limits Bmp2/4 activity to promote neural induction and that <italic> boz</italic> negatively regulates factors such as Wnt8 to promote organizer formation and limit posteriorization of anterior neuroectoderm.
520 $a Lastly, <italic>boz</italic> and <italic>din</italic> double mutant embryos exhibit a synergistic phenotype and do not form a head and trunk. <italic> bmp</italic> expression was greatly expanded in <italic>boz din</italic> mutants, resulting in an expansion of nonneural ectoderm at the expense of neural ectoderm. Furthermore, most mesendodermal precursors experienced high Bmp activity and resided vegetally in the tailbud, resulting in the subsequent contribution of these cells to the tail instead of the head and trunk. These studies indicated <italic> boz</italic> and <italic>din</italic> act in redundant, partially overlapping pathways that are essential to limit Bmp activity dorsally and allow for head and trunk formation.
590 $a School code: 0242.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Neuroscience. $3 1017680
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