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Supercritical Fluid Aided Microencap...

Carvallo, Raquel.

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Supercritical Fluid Aided Microencapsulation of Dry Powders.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Supercritical Fluid Aided Microencapsulation of Dry Powders./
Author:	Carvallo, Raquel.
Description:	222 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .
Contained By:	Dissertation Abstracts International72-10B.
Subject:	Chemistry, Pharmaceutical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3465559
ISBN:	9781124775647

Supercritical Fluid Aided Microencapsulation of Dry Powders.
Carvallo, Raquel.

Supercritical Fluid Aided Microencapsulation of Dry Powders. - 222 p.

Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .

Thesis (Ph.D.)--University of South Florida, 2011.

Coating of fine particles to produce tailored surface properties is currently a key development for supercritical fluids applications, in different areas such as: pharmaceutical, nutraceutical, cosmetic, agrochemical, electronic and specialty chemistry industries. During the encapsulation process the particle surface can be designed with specific properties by spreading a thin film coating material over the surface of the particles.

ISBN: 9781124775647Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Supercritical Fluid Aided Microencapsulation of Dry Powders.
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020 $a 9781124775647
035 $a (UMI)AAI3465559
035 $a AAI3465559
040 $a UMI $c UMI
100 1 $a Carvallo, Raquel. $3 1685194
245 1 0 $a Supercritical Fluid Aided Microencapsulation of Dry Powders.
300 $a 222 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-10, Section: B, page: .
500 $a Adviser: Aydin K. Sunol.
502 $a Thesis (Ph.D.)--University of South Florida, 2011.
520 $a Coating of fine particles to produce tailored surface properties is currently a key development for supercritical fluids applications, in different areas such as: pharmaceutical, nutraceutical, cosmetic, agrochemical, electronic and specialty chemistry industries. During the encapsulation process the particle surface can be designed with specific properties by spreading a thin film coating material over the surface of the particles.
520 $a Chitosan, a natural polymer, was used in this work as the encapsulant material. Chitosan is biocompatible, biodegradable to normal body constituents, safe, non-toxic, bacteriostatic, anticancerogen, and versatile polymer. These attributes are among the properties that make Chitosan an attractive component of pharmaceutical products.
520 $a The main objective of this research was to encapsulate solid particles under 5 m with a biopolymer, Chitosan, using supercritical CO2 as one of the solvents. In order to reach this goal, some the following initial tasks were completed: the cloud point for the system DMSO-CO2 was determined and compared with published data to validate the experimental system. Subsequently the cloud point experiments were extended to include the ternary system Chitosan-DMSO-CO2, and a dynamic solubility experimental set-up was constructed and used to obtain solubility data for the same ternary system.
520 $a A novel SCF fluidized bed was used to micro encapsulate porous (TiO 2) and non-porous particles (CaO) through a temperature swing with a Chitosan thin layer. DMSO was used as an entrainer to enable solubilization of Chitosan and removed within the supercritical carbon dioxide.
520 $a Several analytical methods were used to characterize these particles; SEM-EDS analysis was used to evaluate a group of particles, determining composition and particle diameter on samples up to 900 particles. TEM and AFM confirmed particles of one micron or less were encapsulated with a thickness of less than 5 nm. AFM shows particle roughness on the nanometer range, 46 nm or more for uncoated particles and 2-4 nm for the encapsulated ones.
520 $a FTIR, NMR and DSC-TGA analysis confirmed that the chemical structure of Chitosan remained constant before and after processing, and the changes observed were attributed to some DMSO and moisture adsorbed during the encapsulation process.
590 $a School code: 0206.
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Chemical. $3 1018531
690 $a 0491
690 $a 0495
690 $a 0542
710 2 $a University of South Florida. $b Chemical Engineering. $3 1685195
773 0 $t Dissertation Abstracts International $g 72-10B.
790 1 0 $a Sunol, Aydin K., $e advisor
790 1 0 $a Campbell, Scott W. $e committee member
790 1 0 $a Mohapatra, Shyam $e committee member
790 1 0 $a Shytle, Douglas $e committee member
790 1 0 $a Wolan, John T. $e committee member
790 $a 0206
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3465559