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Vitamin A and the Risk for Melanoma.

Tang, Christopher Ming Tai.

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Vitamin A and the Risk for Melanoma.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Vitamin A and the Risk for Melanoma./
Author:	Tang, Christopher Ming Tai.
Description:	100 p.
Notes:	Source: Masters Abstracts International, Volume: 49-04, page: 2483.
Contained By:	Masters Abstracts International49-04.
Subject:	Health Sciences, Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1489427
ISBN:	9781124511108

Vitamin A and the Risk for Melanoma.
Tang, Christopher Ming Tai.

Vitamin A and the Risk for Melanoma. - 100 p.

Source: Masters Abstracts International, Volume: 49-04, page: 2483.

Thesis (M.S.)--University of California, Irvine, 2011.

Objective. Vitamin A is known as a modulator of gene expression and cellular differentiation. The goal of the this study is to assess the relationship between vitamin A intake and incident melanoma cases in the California Teachers Study Cohort. Hypothesis. Due to the ability of vitamin A to induce cellular differentiation, one may postulate that higher levels of vitamin A intake will be associated with a decreased risk for melanoma. Methods. A cohort of 105,269 female Caucasian teachers from the state of California and under the age of 85 years was studied to assess the relationship between oral vitamin A intake and incident cases of melanoma. Since 1995, 1193 incident cases of melanoma were identified through the California Cancer Registry. 659 of the cases were invasive melanoma and 534 cases were in situ. The confounders were alcohol consumption, skin reaction to sun, skin coloration after tanning, age at first blistering, number of times blistering, being burned enough to cause blistering, family history of melanoma, family history of moles, moles on oneself, BMI, and menopausal status with or without hormone replacement therapy. Hazard ratios and 95% confidence intervals were estimated for vitamin A and related nutrients in relation to melanoma development through Cox proportional hazard models. Results. The analysis showed that there was no relationship between vitamin A intake status and the risk for melanoma. Alcohol consumption appeared to have an association with melanoma as those consuming <20g/d (HR 1.25, 95% CI 1.09-1.43) and >20g/d (HR 1.53, 95% CI 1.25-1.88) had increased risk compared to those who did not drink. Supplemental beta-carotene use greater than 5000 IU also appears to be a risk factor for melanoma (HR 1.22, 95% CI 1.07-1.38) when compared to subjects who did not use supplements.

ISBN: 9781124511108Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Vitamin A and the Risk for Melanoma.
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020 $a 9781124511108
035 $a (UMI)AAI1489427
035 $a AAI1489427
040 $a UMI $c UMI
100 1 $a Tang, Christopher Ming Tai. $3 1684999
245 1 0 $a Vitamin A and the Risk for Melanoma.
300 $a 100 p.
500 $a Source: Masters Abstracts International, Volume: 49-04, page: 2483.
500 $a Adviser: Ronald Shank.
502 $a Thesis (M.S.)--University of California, Irvine, 2011.
520 $a Objective. Vitamin A is known as a modulator of gene expression and cellular differentiation. The goal of the this study is to assess the relationship between vitamin A intake and incident melanoma cases in the California Teachers Study Cohort. Hypothesis. Due to the ability of vitamin A to induce cellular differentiation, one may postulate that higher levels of vitamin A intake will be associated with a decreased risk for melanoma. Methods. A cohort of 105,269 female Caucasian teachers from the state of California and under the age of 85 years was studied to assess the relationship between oral vitamin A intake and incident cases of melanoma. Since 1995, 1193 incident cases of melanoma were identified through the California Cancer Registry. 659 of the cases were invasive melanoma and 534 cases were in situ. The confounders were alcohol consumption, skin reaction to sun, skin coloration after tanning, age at first blistering, number of times blistering, being burned enough to cause blistering, family history of melanoma, family history of moles, moles on oneself, BMI, and menopausal status with or without hormone replacement therapy. Hazard ratios and 95% confidence intervals were estimated for vitamin A and related nutrients in relation to melanoma development through Cox proportional hazard models. Results. The analysis showed that there was no relationship between vitamin A intake status and the risk for melanoma. Alcohol consumption appeared to have an association with melanoma as those consuming <20g/d (HR 1.25, 95% CI 1.09-1.43) and >20g/d (HR 1.53, 95% CI 1.25-1.88) had increased risk compared to those who did not drink. Supplemental beta-carotene use greater than 5000 IU also appears to be a risk factor for melanoma (HR 1.22, 95% CI 1.07-1.38) when compared to subjects who did not use supplements.
590 $a School code: 0030.
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0383
690 $a 0564
690 $a 0570
690 $a 0992
710 2 $a University of California, Irvine. $b Environmental Toxicology - M.S. $3 1685000
773 0 $t Masters Abstracts International $g 49-04.
790 1 0 $a Shank, Ronald, $e advisor
790 1 0 $a Baker, Dean $e committee member
790 1 0 $a Anton-Culver, Hoda $e committee member
790 $a 0030
791 $a M.S.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1489427