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Levels of APP regulate dendritic mor...

Walsh, Jessica Jillian.

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Levels of APP regulate dendritic morphology.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Levels of APP regulate dendritic morphology./
Author:	Walsh, Jessica Jillian.
Description:	50 p.
Notes:	Source: Masters Abstracts International, Volume: 48-05, page: 2874.
Contained By:	Masters Abstracts International48-05.
Subject:	Biology, Neurobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1475620
ISBN:	9781109749205

Levels of APP regulate dendritic morphology.
Walsh, Jessica Jillian.

Levels of APP regulate dendritic morphology. - 50 p.

Source: Masters Abstracts International, Volume: 48-05, page: 2874.

Thesis (M.S.)--Mount Sinai School of Medicine of New York University, 2010.

The amyloid precursor protein (APP) plays a role in the pathogenesis of Alzheimer's disease (AD), with functions including mediation of neurite outgrowth, cell adhesion, and regulation of synaptic plasticity and transmission. However, whether synapse numbers are altered in APP -/- is controversial. In this study we demonstrate that aged APP-/- mice exhibit significant decreases in apical dendritic length and complexity compared to controls. No significant alterations in neuronal morphology were seen in young APP-/- compared to aged APP-/-, suggesting a transgene effect. Finally, when comparing APP homologues we found decreases in apical dendritic length and complexity in APP-/- mice versus APLP2-/- mice. The alterations in the apical dendrites in the absence of APP suggest that APP alone, without the two orthologues, plays a role in synapse formation and that the APP-dependent component of Abeta may induce synaptic damage.

ISBN: 9781109749205Subjects--Topical Terms:

1681328
Biology, Neurobiology.

Levels of APP regulate dendritic morphology.
LDR:01893nam 2200301 4500 001 1404646
005 20111130124110.5
008 130515s2010 ||||||||||||||||| ||eng d
020 $a 9781109749205
035 $a (UMI)AAI1475620
035 $a AAI1475620
040 $a UMI $c UMI
100 1 $a Walsh, Jessica Jillian. $3 1683981
245 1 0 $a Levels of APP regulate dendritic morphology.
300 $a 50 p.
500 $a Source: Masters Abstracts International, Volume: 48-05, page: 2874.
500 $a Adviser: Patrick R. Hof.
502 $a Thesis (M.S.)--Mount Sinai School of Medicine of New York University, 2010.
520 $a The amyloid precursor protein (APP) plays a role in the pathogenesis of Alzheimer's disease (AD), with functions including mediation of neurite outgrowth, cell adhesion, and regulation of synaptic plasticity and transmission. However, whether synapse numbers are altered in APP -/- is controversial. In this study we demonstrate that aged APP-/- mice exhibit significant decreases in apical dendritic length and complexity compared to controls. No significant alterations in neuronal morphology were seen in young APP-/- compared to aged APP-/-, suggesting a transgene effect. Finally, when comparing APP homologues we found decreases in apical dendritic length and complexity in APP-/- mice versus APLP2-/- mice. The alterations in the apical dendrites in the absence of APP suggest that APP alone, without the two orthologues, plays a role in synapse formation and that the APP-dependent component of Abeta may induce synaptic damage.
590 $a School code: 1353.
650 4 $a Biology, Neurobiology. $3 1681328
650 4 $a Health Sciences, Aging. $3 1669845
690 $a 0421
690 $a 0493
710 2 $a Mount Sinai School of Medicine of New York University. $b Neurosciences. $3 1683982
773 0 $t Masters Abstracts International $g 48-05.
790 1 0 $a Hof, Patrick R., $e advisor
790 1 0 $a Gandy, Samuel $e committee member
790 1 0 $a Salton, Stephen $e committee member
790 $a 1353
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1475620