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切換: 標籤 | MARC模式 | ISBD

Levels of APP regulate dendritic mor...

Walsh, Jessica Jillian.

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Levels of APP regulate dendritic morphology.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Levels of APP regulate dendritic morphology./
作者:	Walsh, Jessica Jillian.
面頁冊數:	50 p.
附註:	Source: Masters Abstracts International, Volume: 48-05, page: 2874.
Contained By:	Masters Abstracts International48-05.
標題:	Biology, Neurobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1475620
ISBN:	9781109749205

Levels of APP regulate dendritic morphology.
Walsh, Jessica Jillian.

Levels of APP regulate dendritic morphology. - 50 p.

Source: Masters Abstracts International, Volume: 48-05, page: 2874.

Thesis (M.S.)--Mount Sinai School of Medicine of New York University, 2010.

The amyloid precursor protein (APP) plays a role in the pathogenesis of Alzheimer's disease (AD), with functions including mediation of neurite outgrowth, cell adhesion, and regulation of synaptic plasticity and transmission. However, whether synapse numbers are altered in APP -/- is controversial. In this study we demonstrate that aged APP-/- mice exhibit significant decreases in apical dendritic length and complexity compared to controls. No significant alterations in neuronal morphology were seen in young APP-/- compared to aged APP-/-, suggesting a transgene effect. Finally, when comparing APP homologues we found decreases in apical dendritic length and complexity in APP-/- mice versus APLP2-/- mice. The alterations in the apical dendrites in the absence of APP suggest that APP alone, without the two orthologues, plays a role in synapse formation and that the APP-dependent component of Abeta may induce synaptic damage.

ISBN: 9781109749205Subjects--Topical Terms:

1681328
Biology, Neurobiology.

Levels of APP regulate dendritic morphology.
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502 $a Thesis (M.S.)--Mount Sinai School of Medicine of New York University, 2010.
520 $a The amyloid precursor protein (APP) plays a role in the pathogenesis of Alzheimer's disease (AD), with functions including mediation of neurite outgrowth, cell adhesion, and regulation of synaptic plasticity and transmission. However, whether synapse numbers are altered in APP -/- is controversial. In this study we demonstrate that aged APP-/- mice exhibit significant decreases in apical dendritic length and complexity compared to controls. No significant alterations in neuronal morphology were seen in young APP-/- compared to aged APP-/-, suggesting a transgene effect. Finally, when comparing APP homologues we found decreases in apical dendritic length and complexity in APP-/- mice versus APLP2-/- mice. The alterations in the apical dendrites in the absence of APP suggest that APP alone, without the two orthologues, plays a role in synapse formation and that the APP-dependent component of Abeta may induce synaptic damage.
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