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The regulation of RANK and RANKL mRN...

Praetorius, Lisa J.

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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c)./
作者:	Praetorius, Lisa J.
面頁冊數:	95 p.
附註:	Source: Masters Abstracts International, Volume: 48-04, page: 2130.
Contained By:	Masters Abstracts International48-04.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR57842
ISBN:	9780494578421

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
Praetorius, Lisa J.

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c). - 95 p.

Source: Masters Abstracts International, Volume: 48-04, page: 2130.

Thesis (M.Sc.)--University of Ontario Institute of Technology (Canada), 2009.

The receptor activator of nuclear factor-kappaB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell signaling pathway is also crucial to breast biology and is involved in transcriptional regulation of many genes. The objective of this study is to determine if RANKL mRNA expression is regulated through the JAK/STAT5a pathway by stimulating human breast cancer cell lines, MCF-7 and MDA-MB-231, with prolactin (PRL), epidermal growth factor (EGF) and heregulin-beta1 (HRG-beta1), all known to activate STAT5a and play a role in breast cancer progression. This study shows that RANKL expression is upregulated by PRL, EGF and HRG-beta1, and that PRL and HRG-beta1 regulate transcription through the JAK/STAT5a pathway.

ISBN: 9780494578421Subjects--Topical Terms:

1017719
Biology, Molecular.

The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
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245 1 4 $a The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines(c).
300 $a 95 p.
500 $a Source: Masters Abstracts International, Volume: 48-04, page: 2130.
502 $a Thesis (M.Sc.)--University of Ontario Institute of Technology (Canada), 2009.
520 $a The receptor activator of nuclear factor-kappaB (RANK) and its ligand, RANKL has have been implicated as an important link between breast cancer and metastasis to bone because of their ability to activate intracellular signal cascades leading to altered cancer cell behaviour and bone breakdown. The JAK/STAT5a cell signaling pathway is also crucial to breast biology and is involved in transcriptional regulation of many genes. The objective of this study is to determine if RANKL mRNA expression is regulated through the JAK/STAT5a pathway by stimulating human breast cancer cell lines, MCF-7 and MDA-MB-231, with prolactin (PRL), epidermal growth factor (EGF) and heregulin-beta1 (HRG-beta1), all known to activate STAT5a and play a role in breast cancer progression. This study shows that RANKL expression is upregulated by PRL, EGF and HRG-beta1, and that PRL and HRG-beta1 regulate transcription through the JAK/STAT5a pathway.
520 $a Keywords. RANKL, STAT5, breast cancer, prolactin, epidermal growth factor, heregulin
590 $a School code: 1555.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
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