語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The role of the type I insulin-like ...
~
Siwicky, Megan Danielle.
FindBook
Google Book
Amazon
博客來
The role of the type I insulin-like growth factor receptor in lung tumorigenesis.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
The role of the type I insulin-like growth factor receptor in lung tumorigenesis./
作者:
Siwicky, Megan Danielle.
面頁冊數:
139 p.
附註:
Source: Masters Abstracts International, Volume: 48-04, page: 2242.
Contained By:
Masters Abstracts International48-04.
標題:
Biology, Cell. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR56778
ISBN:
9780494567784
The role of the type I insulin-like growth factor receptor in lung tumorigenesis.
Siwicky, Megan Danielle.
The role of the type I insulin-like growth factor receptor in lung tumorigenesis.
- 139 p.
Source: Masters Abstracts International, Volume: 48-04, page: 2242.
Thesis (M.Sc.)--University of Guelph (Canada), 2009.
The type I insulin-like growth factor receptor (IGF-IR) has been observed to be overexpressed in the majority lung cancer cell lines and human lung tumor biopsies. Two doxycycline-inducible transgenic mouse models in which the IGF-IR was overexpressed in either the Clara cells or the type II alveolar cells of the lung were used in this study. It was discovered that mice overexpressing IGF-IR in the type II alveolar cells of the lung developed a greater tumor burden than mice overexpressing IGF-IR in the Clara cells. Tumors were also found to develop more quickly in mice overexpressing IGF-IR in the type II alveolar cells of the lung that were treated with doxycycline in utero in comparison to postnatally, however this finding was not statistically significant. The interaction between nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and the IGF-IR was then investigated in this study, and NNK was injected into both of the transgenic mouse models. No significant differences in tumor development were found between transgenic mice that received NNK injections and those that did not. However, endogenous murine IGF-IR was found to be expressed at high levels in the tumors that developed in the wildtype NNK injected mice, providing evidence that the IGF-IR may playa significant role in mediating the carcinogenic effects of NNK.
ISBN: 9780494567784Subjects--Topical Terms:
1017686
Biology, Cell.
The role of the type I insulin-like growth factor receptor in lung tumorigenesis.
LDR
:02171nam 2200265 4500
001
1403603
005
20111118100017.5
008
130515s2009 ||||||||||||||||| ||eng d
020
$a
9780494567784
035
$a
(UMI)AAIMR56778
035
$a
AAIMR56778
040
$a
UMI
$c
UMI
100
1
$a
Siwicky, Megan Danielle.
$3
1682878
245
1 4
$a
The role of the type I insulin-like growth factor receptor in lung tumorigenesis.
300
$a
139 p.
500
$a
Source: Masters Abstracts International, Volume: 48-04, page: 2242.
502
$a
Thesis (M.Sc.)--University of Guelph (Canada), 2009.
520
$a
The type I insulin-like growth factor receptor (IGF-IR) has been observed to be overexpressed in the majority lung cancer cell lines and human lung tumor biopsies. Two doxycycline-inducible transgenic mouse models in which the IGF-IR was overexpressed in either the Clara cells or the type II alveolar cells of the lung were used in this study. It was discovered that mice overexpressing IGF-IR in the type II alveolar cells of the lung developed a greater tumor burden than mice overexpressing IGF-IR in the Clara cells. Tumors were also found to develop more quickly in mice overexpressing IGF-IR in the type II alveolar cells of the lung that were treated with doxycycline in utero in comparison to postnatally, however this finding was not statistically significant. The interaction between nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and the IGF-IR was then investigated in this study, and NNK was injected into both of the transgenic mouse models. No significant differences in tumor development were found between transgenic mice that received NNK injections and those that did not. However, endogenous murine IGF-IR was found to be expressed at high levels in the tumors that developed in the wildtype NNK injected mice, providing evidence that the IGF-IR may playa significant role in mediating the carcinogenic effects of NNK.
590
$a
School code: 0081.
650
4
$a
Biology, Cell.
$3
1017686
650
4
$a
Biology, Physiology.
$3
1017816
650
4
$a
Health Sciences, Oncology.
$3
1018566
690
$a
0379
690
$a
0719
690
$a
0992
710
2
$a
University of Guelph (Canada).
$3
1018650
773
0
$t
Masters Abstracts International
$g
48-04.
790
$a
0081
791
$a
M.Sc.
792
$a
2009
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR56778
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9166742
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入