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Abelson family kinases regulate acti...

Talaei, Nafiseh.

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Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration./
作者:	Talaei, Nafiseh.
面頁冊數:	129 p.
附註:	Source: Masters Abstracts International, Volume: 48-02, page: 0984.
Contained By:	Masters Abstracts International48-02.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR52687
ISBN:	9780494526873

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.
Talaei, Nafiseh.

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration. - 129 p.

Source: Masters Abstracts International, Volume: 48-02, page: 0984.

Thesis (M.Sc.)--University of Toronto (Canada), 2009.

The Abelson family protein tyrosine kinases (Abl-PTKs) consist of c-Abl and Arg, and can regulate F-actin structures within the cellular cytoskeleton. Actin polymerization plays a fundamental role in regulating T cell receptor-induced immunological synapse (IS) formation and chemokine-induced T cell migration. Conditional deletion of Abl-PTKs (Ts-DKO) in T lymphocytes reveals the role of Abl-PTKs in regulation of F-actin remodeling in IS formation and SDF-1alpha-induced T cell migration. Ts-DKO T cells exhibit excessive accumulation of F-actin at the IS, which is correlated with the modulation of the guanine nucleotide exchange factor (GEF) activity of Vav, since downregularion of Vav by Cbl requires phosphorylation by Abl-PTKs. In addition, we show that Ts-DKO T cells exhibit reduced T cell migration, actin reorganization and polarization in response to SDF-1alpha. Taken together, our results identify Abl-PTKs as key regulators of F-actin structures in IS and CXCR4 receptor-mediated T cell migration.

ISBN: 9780494526873Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Abelson family kinases regulate actin cytoskeleton dynamics in immunological synapse formation and T cell migration.
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520 $a The Abelson family protein tyrosine kinases (Abl-PTKs) consist of c-Abl and Arg, and can regulate F-actin structures within the cellular cytoskeleton. Actin polymerization plays a fundamental role in regulating T cell receptor-induced immunological synapse (IS) formation and chemokine-induced T cell migration. Conditional deletion of Abl-PTKs (Ts-DKO) in T lymphocytes reveals the role of Abl-PTKs in regulation of F-actin remodeling in IS formation and SDF-1alpha-induced T cell migration. Ts-DKO T cells exhibit excessive accumulation of F-actin at the IS, which is correlated with the modulation of the guanine nucleotide exchange factor (GEF) activity of Vav, since downregularion of Vav by Cbl requires phosphorylation by Abl-PTKs. In addition, we show that Ts-DKO T cells exhibit reduced T cell migration, actin reorganization and polarization in response to SDF-1alpha. Taken together, our results identify Abl-PTKs as key regulators of F-actin structures in IS and CXCR4 receptor-mediated T cell migration.
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