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MicroRNA pathways modulate aging and...

Liu, Nan.

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MicroRNA pathways modulate aging and neurodegenerative diseases.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	MicroRNA pathways modulate aging and neurodegenerative diseases./
作者:	Liu, Nan.
面頁冊數:	143 p.
附註:	Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0097.
Contained By:	Dissertation Abstracts International71-01B.
標題:	Biology, Molecular. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3395704
ISBN:	9781109582000

MicroRNA pathways modulate aging and neurodegenerative diseases.
Liu, Nan.

MicroRNA pathways modulate aging and neurodegenerative diseases. - 143 p.

Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0097.

Thesis (Ph.D.)--University of Pennsylvania, 2009.

Aging is the most prominent risk factor for human neurodegenerative diseases. Defining a novel component that modulates aging would provide new insight into this type of age-related diseases. miRNAs are small regulatory RNAs that have been shown to regulate diverse biological processes. In this study, we first define a conserved role for miRNA pathways, in both human cells and in flies, to modulate the polyglutamine-induced neurodegenerative disease. We next identify a conserved miRNA, miR-34 as a novel component in the age-induced response. We further show that miR-34 is an integral component in regulation of aging: while lack of miR-34 triggers accelerated aging, overexpression of miR-34 protects against neurodegenerative disease-associated proteotoxicity. Taken together, our study indicates that miRNA pathways may play an intrinsic role in modulation of aging, and this role may have a profound impact on many age-related processes, including neurodegenerative diseases.

ISBN: 9781109582000Subjects--Topical Terms:

1017719
Biology, Molecular.

MicroRNA pathways modulate aging and neurodegenerative diseases.
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520 $a Aging is the most prominent risk factor for human neurodegenerative diseases. Defining a novel component that modulates aging would provide new insight into this type of age-related diseases. miRNAs are small regulatory RNAs that have been shown to regulate diverse biological processes. In this study, we first define a conserved role for miRNA pathways, in both human cells and in flies, to modulate the polyglutamine-induced neurodegenerative disease. We next identify a conserved miRNA, miR-34 as a novel component in the age-induced response. We further show that miR-34 is an integral component in regulation of aging: while lack of miR-34 triggers accelerated aging, overexpression of miR-34 protects against neurodegenerative disease-associated proteotoxicity. Taken together, our study indicates that miRNA pathways may play an intrinsic role in modulation of aging, and this role may have a profound impact on many age-related processes, including neurodegenerative diseases.
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