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Toxicological and pharmacological ac...

Zhang, Yongbin.

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Toxicological and pharmacological actions of engineered nanomaterials.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Toxicological and pharmacological actions of engineered nanomaterials./
Author:	Zhang, Yongbin.
Description:	161 p.
Notes:	Source: Dissertation Abstracts International, Volume: 70-07, Section: B, page: 4134.
Contained By:	Dissertation Abstracts International70-07B.
Subject:	Health Sciences, Occupational Health and Safety. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3366222
ISBN:	9781109270204

Toxicological and pharmacological actions of engineered nanomaterials.
Zhang, Yongbin.

Toxicological and pharmacological actions of engineered nanomaterials. - 161 p.

Source: Dissertation Abstracts International, Volume: 70-07, Section: B, page: 4134.

Thesis (Ph.D.)--Oklahoma State University, 2009.

Scope and method of study. The toxicity of selected synthetic nanomaterials was studied using both in vitro and in vivo approaches. The toxicity of inorganic CdTe nanoparticles was first evaluated using both human HepG2 cells in vitro and systemic exposure in male rats in vivo. Cytotoxicity of organic fullerene aggregates was also evaluated in HepG2 cells. The potential utility of zinc oxide nanomaterials conjugated to a porphyrin derivative in the photodynamic therapy of ovarian cancer cells in vitro was evaluated. Mechanistic studies to determine the role of reactive oxygen species and oxidative stress in the cytotoxicity of all of these nanomaterials were conducted. A number of techniques/approaches including neurobehavioral assessments, biochemical assays, real-time PCR, western blotting, and both electron and confocal microscopy were used to address the biological consequences of nanomaterial exposure.

ISBN: 9781109270204Subjects--Topical Terms:

1017799
Health Sciences, Occupational Health and Safety.

Toxicological and pharmacological actions of engineered nanomaterials.
LDR:02910nam 2200349 4500 001 1403476
005 20111118095932.5
008 130515s2009 ||||||||||||||||| ||eng d
020 $a 9781109270204
035 $a (UMI)AAI3366222
035 $a AAI3366222
040 $a UMI $c UMI
100 1 $a Zhang, Yongbin. $3 1682736
245 1 0 $a Toxicological and pharmacological actions of engineered nanomaterials.
300 $a 161 p.
500 $a Source: Dissertation Abstracts International, Volume: 70-07, Section: B, page: 4134.
500 $a Adviser: Carey Pope.
502 $a Thesis (Ph.D.)--Oklahoma State University, 2009.
520 $a Scope and method of study. The toxicity of selected synthetic nanomaterials was studied using both in vitro and in vivo approaches. The toxicity of inorganic CdTe nanoparticles was first evaluated using both human HepG2 cells in vitro and systemic exposure in male rats in vivo. Cytotoxicity of organic fullerene aggregates was also evaluated in HepG2 cells. The potential utility of zinc oxide nanomaterials conjugated to a porphyrin derivative in the photodynamic therapy of ovarian cancer cells in vitro was evaluated. Mechanistic studies to determine the role of reactive oxygen species and oxidative stress in the cytotoxicity of all of these nanomaterials were conducted. A number of techniques/approaches including neurobehavioral assessments, biochemical assays, real-time PCR, western blotting, and both electron and confocal microscopy were used to address the biological consequences of nanomaterial exposure.
520 $a Findings and conclusions. (1) CdTe nanoparticle-induced cytotoxicity is size- and concentration-dependent, involving caspase(s) activation, DNA fragmentation and metallothionein induction, but apparently not oxidative stress. (2) CdTe altered motor activity following in vivo dosing, suggesting possible disruption of nervous system function. (3) Subcellular distribution of CdTe was size- and time- dependent. (4) Intact CdTe nanoparticles appeared to distribute into tissues following intravenous administration in rats. (5) Surface properties, size, chemical composition, and purity of nanomaterial preparations can all contribute to nanotoxicity. (6) Fullerene aggregates appeared to elicit cytotoxicity via oxidative stress. (7) ZnO conjugates elicited selective phototoxicity involving both apoptosis and necrosis, mediated by caspase(s) activation and oxidative stress.
590 $a School code: 0664.
650 4 $a Health Sciences, Occupational Health and Safety. $3 1017799
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0354
690 $a 0383
690 $a 0419
710 2 $a Oklahoma State University. $b Veterinary Biomedical Sciences. $3 1021731
773 0 $t Dissertation Abstracts International $g 70-07B.
790 1 0 $a Pope, Carey, $e advisor
790 1 0 $a Breshears, Melanie $e committee member
790 1 0 $a Chen, Guangping $e committee member
790 1 0 $a Ausman, Kevin $e committee member
790 1 0 $a Davis, Michael $e committee member
790 $a 0664
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3366222