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Lateral transfer and Chlamydia a phy...

Gooden, Stacy-Ann.

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Lateral transfer and Chlamydia a phylogenetic and genomic approach to Chlamydia evolution.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Lateral transfer and Chlamydia a phylogenetic and genomic approach to Chlamydia evolution./
作者:	Gooden, Stacy-Ann.
面頁冊數:	102 p.
附註:	Source: Masters Abstracts International, Volume: 49-01, page: 0255.
Contained By:	Masters Abstracts International49-01.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1485857
ISBN:	9781124182827

Lateral transfer and Chlamydia a phylogenetic and genomic approach to Chlamydia evolution.
Gooden, Stacy-Ann.

Lateral transfer and Chlamydia a phylogenetic and genomic approach to Chlamydia evolution. - 102 p.

Source: Masters Abstracts International, Volume: 49-01, page: 0255.

Thesis (M.S.)--Long Island University, The Brooklyn Center, 2011.

Chlamydia trachomatis is an obligate intracellular gram negative bacterium that causes a variety of diseases in many eukaryotes. In humans Chlamydia trachomatis 434/Bu causes the sexual transmitted disease Chlamydia which can lead to blindness and infertility. The interaction between the bacterium and the host is still not fully understood, and only a few studies have been done to highlight this interaction. The research presented here involved analysis of possible gene transfer (lateral gene transfer) between Chlamydia trachomatis genome and host genomes using an evolutionary genomic approach. The goal of this research was to find if any host genes were also found in the Chlamydia trachomatis genome. Lateral transfer was seen on phylogenetic trees, and there was some evidence that Chlamydia trachomatis may have obtained genes from eukaryotic species such as humans and plants. Three potential genes for lateral transfer between Chlamydia trachomatis and host species were found. The first potential candidate for lateral gene transfer is the human TPR 1 gene which may have transferred into the Chlamydia trachomatis genome anciently. Two other genes of potential lateral transfer between hosts and Chlamydia trachomatis genomes are the amino acid transporter gene and ribonucleoside-diphosphate reductase large subunit gene. The last two genes are candidates for a more recent lateral transfer. In addition to gene transfer the Chlamydia trachomatis genome was analyzed for genes under positive selection and purifying selection as indicated by the pattern of changes in amino acids. The method used to detect selection was quantitative analysis of synonymous and nonsynonymous mutations. There was evidence of gene selection in Chlamydia trachomatis especially for inclusion membrane and outer membrane proteins. The genes identified in this thesis might facilitate understanding the unique mode of pathogenesis of Chlamydia trachomatis.

ISBN: 9781124182827Subjects--Topical Terms:

1017734
Biology, Microbiology.

Lateral transfer and Chlamydia a phylogenetic and genomic approach to Chlamydia evolution.
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500 $a Adviser: Lorraine Marsh.
502 $a Thesis (M.S.)--Long Island University, The Brooklyn Center, 2011.
520 $a Chlamydia trachomatis is an obligate intracellular gram negative bacterium that causes a variety of diseases in many eukaryotes. In humans Chlamydia trachomatis 434/Bu causes the sexual transmitted disease Chlamydia which can lead to blindness and infertility. The interaction between the bacterium and the host is still not fully understood, and only a few studies have been done to highlight this interaction. The research presented here involved analysis of possible gene transfer (lateral gene transfer) between Chlamydia trachomatis genome and host genomes using an evolutionary genomic approach. The goal of this research was to find if any host genes were also found in the Chlamydia trachomatis genome. Lateral transfer was seen on phylogenetic trees, and there was some evidence that Chlamydia trachomatis may have obtained genes from eukaryotic species such as humans and plants. Three potential genes for lateral transfer between Chlamydia trachomatis and host species were found. The first potential candidate for lateral gene transfer is the human TPR 1 gene which may have transferred into the Chlamydia trachomatis genome anciently. Two other genes of potential lateral transfer between hosts and Chlamydia trachomatis genomes are the amino acid transporter gene and ribonucleoside-diphosphate reductase large subunit gene. The last two genes are candidates for a more recent lateral transfer. In addition to gene transfer the Chlamydia trachomatis genome was analyzed for genes under positive selection and purifying selection as indicated by the pattern of changes in amino acids. The method used to detect selection was quantitative analysis of synonymous and nonsynonymous mutations. There was evidence of gene selection in Chlamydia trachomatis especially for inclusion membrane and outer membrane proteins. The genes identified in this thesis might facilitate understanding the unique mode of pathogenesis of Chlamydia trachomatis.
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