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Systems modeling of the oral metabiome.

Brown, Robert E.

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Systems modeling of the oral metabiome.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Systems modeling of the oral metabiome./
作者:	Brown, Robert E.
面頁冊數:	134 p.
附註:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
標題:	Biology, Systematic. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3455043
ISBN:	9781124617282

Systems modeling of the oral metabiome.
Brown, Robert E.

Systems modeling of the oral metabiome. - 134 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--George Mason University, 2011.

Deciphering the underlying biological processes comprising the Human Oral Metabiome is important to the understanding of Human Immunodeficiency Virus (HIV) disease. The National Institute of Health has launched the Human Microbiome Project (HMP) to accelerate research and discovery techniques for five microbiome sites on the human body. Knowledge discovery techniques are needed to point researchers to follow-on hypotheses to quickly pinpoint areas of great promise. We developed the Differential Correlation Network (DCN) as a technique for researcher's to perform knowledge discovery in the oral mycobiome field. Using data from the Oral Microbiome, Differential Correlation Networks were applied to metabolites, bacteria, and fungi sampled from 12 Controls and 12 HIV Patients. By analyzing 100's of features across disease vs. control classes, statistically significant feature pair differences are captured and presented in Cytoscape. Several interesting differences are discovered and their possible biological significance is presented. The Systems model in conjunction with known biological metadata can identify promising difference networks and direct follow-on research based on DCN generated hypothesis.

ISBN: 9781124617282Subjects--Topical Terms:

1676856
Biology, Systematic.

Systems modeling of the oral metabiome.
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