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Genomic versatility in the Burkholde...

Chain, Patrick S. G.

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Genomic versatility in the Burkholderia genus: From strains to species.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genomic versatility in the Burkholderia genus: From strains to species./
Author:	Chain, Patrick S. G.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3450958
ISBN:	9781124605272

Genomic versatility in the Burkholderia genus: From strains to species.
Chain, Patrick S. G.

Genomic versatility in the Burkholderia genus: From strains to species. - 174 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--Michigan State University, 2011.

DNA sequencing has for years helped illuminate the extent of microbial diversity and their phylogenetic relationship, and more recently breathed life into most scientific disciplines, including microbiology, by allowing a complete understanding of genomic structure, functional potential, and patterns of evolution via whole genome sequencing of many species and strains. While the precise definition of bacterial species is still murky, it is clear that the group of closely related organisms classified as Burkholderia encompass a very impressive array of phenotypic properties. Using a multitude of genomic and bioinformatic methods, this thesis explores the similarities and differences at various taxonomic levels among genomes sequenced from this genus, attempts to relate some of these discoveries to other species, and discusses the implications of these findings on broader scientific questions. Pangenomic analyses among species of Burkholderia reveal an impressive array of variable genes that are not shared among all member of the genus, while comparative pangenomic analysis among strains of the same species clearly show the conservation of its main chromosome and the accelerated rate of evolution in the accessory chromosomes. A lineage-specific analysis of clinical specimens isolated over the course of 20 years reveals the evolutionary strategy for an organism highly adapted to its niche. It is clear that at all levels, the Burkholderia display remarkable genomic diversity, enabled in part by their large multi-replicon genome, and responsible for their amazing phenotypic versatility.

ISBN: 9781124605272Subjects--Topical Terms:

1017734
Biology, Microbiology.

Genomic versatility in the Burkholderia genus: From strains to species.
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020 $a 9781124605272
035 $a (UMI)AAI3450958
035 $a AAI3450958
040 $a UMI $c UMI
100 1 $a Chain, Patrick S. G. $3 1682304
245 1 0 $a Genomic versatility in the Burkholderia genus: From strains to species.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
500 $a Adviser: James M. Tiedje.
502 $a Thesis (Ph.D.)--Michigan State University, 2011.
520 $a DNA sequencing has for years helped illuminate the extent of microbial diversity and their phylogenetic relationship, and more recently breathed life into most scientific disciplines, including microbiology, by allowing a complete understanding of genomic structure, functional potential, and patterns of evolution via whole genome sequencing of many species and strains. While the precise definition of bacterial species is still murky, it is clear that the group of closely related organisms classified as Burkholderia encompass a very impressive array of phenotypic properties. Using a multitude of genomic and bioinformatic methods, this thesis explores the similarities and differences at various taxonomic levels among genomes sequenced from this genus, attempts to relate some of these discoveries to other species, and discusses the implications of these findings on broader scientific questions. Pangenomic analyses among species of Burkholderia reveal an impressive array of variable genes that are not shared among all member of the genus, while comparative pangenomic analysis among strains of the same species clearly show the conservation of its main chromosome and the accelerated rate of evolution in the accessory chromosomes. A lineage-specific analysis of clinical specimens isolated over the course of 20 years reveals the evolutionary strategy for an organism highly adapted to its niche. It is clear that at all levels, the Burkholderia display remarkable genomic diversity, enabled in part by their large multi-replicon genome, and responsible for their amazing phenotypic versatility.
590 $a School code: 0128.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Evolution and Development. $3 1675612
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0410
690 $a 0412
690 $a 0715
710 2 $a Michigan State University. $b Microbiology and Molecular Genetics. $3 1682305
773 0 $t Dissertation Abstracts International $g 72-07B.
790 1 0 $a Tiedje, James M., $e advisor
790 1 0 $a Lenski, Richard E. $e committee member
790 1 0 $a LiPuma, John J. $e committee member
790 1 0 $a Marsh, Terence L. $e committee member
790 1 0 $a Schmidt, Thomas M. $e committee member
790 $a 0128
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3450958