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HIV initiates multiple signaling cas...
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Kelly, Jeremy.
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HIV initiates multiple signaling cascades required for effective replication.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
HIV initiates multiple signaling cascades required for effective replication./
作者:
Kelly, Jeremy.
面頁冊數:
144 p.
附註:
Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2237.
Contained By:
Dissertation Abstracts International71-04B.
標題:
Biology, Molecular. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3405157
ISBN:
9781109707533
HIV initiates multiple signaling cascades required for effective replication.
Kelly, Jeremy.
HIV initiates multiple signaling cascades required for effective replication.
- 144 p.
Source: Dissertation Abstracts International, Volume: 71-04, Section: B, page: 2237.
Thesis (Ph.D.)--George Mason University, 2010.
The Human Immunodeficiency Virus (HIV) infects lymphocytes by binding to CD4 and either the CXCR4 or CCR5 receptor. Signaling initiated by these receptors in response to the virus was found to be unnecessary for viral infection. Recent work by the Wu lab has demonstrated that in resting CD4 T cells CXCR4 signaling is necessary to overcome cortical actin restriction. Here we show that multiple signaling cascades are not only initiated by HIV and CD4/CXCR4 signaling, but that this signaling can impact viral replication in non-resting cells. We specifically identify the JAK/STAT pathway as a necessary component of early viral transcription; which has implications for not only novel therapeutics but also for understanding how we view viral interactions with the immune system.
ISBN: 9781109707533Subjects--Topical Terms:
1017719
Biology, Molecular.
HIV initiates multiple signaling cascades required for effective replication.
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