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Stromal changes and transforming gro...

De Vries, Lindsey.

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Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows./
作者:	De Vries, Lindsey.
面頁冊數:	85 p.
附註:	Source: Masters Abstracts International, Volume: 47-06, page: 3337.
Contained By:	Masters Abstracts International47-06.
標題:	Agriculture, Animal Culture and Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1468323
ISBN:	9781109242836

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.
De Vries, Lindsey.

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows. - 85 p.

Source: Masters Abstracts International, Volume: 47-06, page: 3337.

Thesis (M.S.)--Michigan State University, 2009.

Our first objective was to determine if mammary remodeling during the dry period of dairy cows is characterized by a transient increase in stromal fibronectin, myofibroblasts, stromelysin (MMP-3), transforming growth factor-beta1 (TGF-beta1) and its receptor, TGF-betaR2. The second objective was to determine if TGF-beta1 increases mammary stromal remodeling during the dry period. Mammary biopsies were obtained from nine cows at: late lactation, 1 week after dry-off, 3 weeks before expected calving, and 1 week before expected calving. For objective 2, tissue was incubated for 2 h with 0 or 5 ng TGF-beta1/ml. Intralobular stromal area was greater at 1 week dry and 3 weeks before calving than at 1 week before calving (P=0.02). The number of fibroblasts was greater at one week dry than 1 week before calving (P=0.02). Stromal TGF-beta1 was 15% lower during the dry period than in late lactation (P=0.02). The number of myofibroblasts and the expression of fibronectin, MMP-3, or TGF-betaR2 did not differ. Incubation with TGF-beta1 had no effect on the percent intralobular stroma area expression of fibronectin or MMP-3. The number of myofibroblasts increased by 19% in the intralobular stroma (P=0.03) and the percent of myofibroblasts tended to increase by 4% (P=0.06) in tissue incubated with TGF-beta1. Based on these findings, TGF-beta1 may be important in the activation of stromal cells during involution and mammogenesis of the bovine mammary gland.

ISBN: 9781109242836Subjects--Topical Terms:

1017857
Agriculture, Animal Culture and Nutrition.

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.
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