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Applications of DNA Nanomechanical D...

Liu, Chunhua.

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Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion./
Author:	Liu, Chunhua.
Description:	216 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-01, Section: B, page: .
Contained By:	Dissertation Abstracts International72-01B.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3427948
ISBN:	9781124331508

Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion.
Liu, Chunhua.

Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion. - 216 p.

Source: Dissertation Abstracts International, Volume: 72-01, Section: B, page: .

Thesis (Ph.D.)--New York University, 2010.

Not merely is DNA a favorable genetic material, but an effective supermolecular subunit for nanoconstruction as well. In structural DNA nanotechnology, rigid branched DNA motifs have been combined with sticky-ended cohesion to build DNA objects, arrays and devices for functional purposes.

ISBN: 9781124331508Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion.
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020 $a 9781124331508
035 $a (UMI)AAI3427948
035 $a AAI3427948
040 $a UMI $c UMI
100 1 $a Liu, Chunhua. $3 1675514
245 1 0 $a Applications of DNA Nanomechanical Devices to Molecular Biology and to Programmed Dynamic Motion.
300 $a 216 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-01, Section: B, page: .
500 $a Adviser: Nadrian C. Seeman.
502 $a Thesis (Ph.D.)--New York University, 2010.
520 $a Not merely is DNA a favorable genetic material, but an effective supermolecular subunit for nanoconstruction as well. In structural DNA nanotechnology, rigid branched DNA motifs have been combined with sticky-ended cohesion to build DNA objects, arrays and devices for functional purposes.
520 $a Reciprocating devices are key features in macroscopic machines. In Chapter II, I report the construction of two reciprocal PX-JX2 devices, wherein the control strands leading to the PX state in one device lead to the JX2 state in the other device, and vice versa. The formation, transformation and reciprocal motions of these two devices are confirmed utilizing gel electrophoresis, and atomic force microscopy. This system is likely to be of use for molecular robotic applications where reciprocal motions are of value in addition its inherent contribution to molecular choreography and molecular aesthetics.
520 $a Recently, several DNA-based nanomechanical devices have been developed as an attractive tool for fine measurements on nanoscale objects. In Chapter III, I have constructed a device wherein two DNA triple crossover (TX) molecules are connected by a shaft, similar to a previous device that measured the amount of work that can be performed by integration host factor [Shen, W., Bruist, M., Goodman, S. & Seeman, N. C., Angew. Chemie Int. Ed. 43, 4750-4752 (2004)]. In the present case, the binding site on the shaft contains the sequence recognized by apo-SoxR, the apo-form of a protein that is a redox-sensing transcriptional activator; previous data suggest that it distorts its binding site by an amount that corresponds to about two base pairs. A pair of dyes reports the fluorescence resonance energy transfer (FRET) signal between the two TX domains, reflecting changes in the shape of the device upon binding the protein. The TX domains are used to amplify the signal expected from a relatively small distortion of the DNA binding site. From FRET analysis of apo-SoxR binding, the effect of apo-SoxR on the original TX device is similar to the effect of shortening the TX device by 2-bp. It is estimated that apo-SoxR can do 3.2-6.1 Kcal/mol of work on the DNA target site.
590 $a School code: 0146.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Nanoscience. $3 587832
650 4 $a Nanotechnology. $3 526235
690 $a 0487
690 $a 0565
690 $a 0652
710 2 $a New York University. $b Chemistry. $3 1064483
773 0 $t Dissertation Abstracts International $g 72-01B.
790 1 0 $a Seeman, Nadrian C., $e advisor
790 1 0 $a Canary, James $e committee member
790 1 0 $a Vologodskii, Alexander $e committee member
790 1 0 $a Jerschow, Alexej $e committee member
790 1 0 $a Arora, Paramjit $e committee member
790 $a 0146
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3427948