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Directed self-assembly of biomolecul...

Wong, Ian Y.

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Directed self-assembly of biomolecules using counterion-screened electric fields.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Directed self-assembly of biomolecules using counterion-screened electric fields./
作者:	Wong, Ian Y.
面頁冊數:	120 p.
附註:	Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0602.
Contained By:	Dissertation Abstracts International71-01B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3395864
ISBN:	9781109585254

Directed self-assembly of biomolecules using counterion-screened electric fields.
Wong, Ian Y.

Directed self-assembly of biomolecules using counterion-screened electric fields. - 120 p.

Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0602.

Thesis (Ph.D.)--Stanford University, 2010.

The development of novel interfaces between electronic devices and biological systems may enable new technological approaches for engineering nanostructures, clinical diagnostics and therapeutic treatments. In particular, the translation of electrical information into biochemical signals can be used to replicate the dynamic behavior of biological systems. This can be accomplished through the use of counterion-screened electric fields to locally perturb the ionic and electrostatic environment near an electrode surface, triggering the assembly and disassembly of biomolecules.

ISBN: 9781109585254Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Directed self-assembly of biomolecules using counterion-screened electric fields.
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502 $a Thesis (Ph.D.)--Stanford University, 2010.
520 $a The development of novel interfaces between electronic devices and biological systems may enable new technological approaches for engineering nanostructures, clinical diagnostics and therapeutic treatments. In particular, the translation of electrical information into biochemical signals can be used to replicate the dynamic behavior of biological systems. This can be accomplished through the use of counterion-screened electric fields to locally perturb the ionic and electrostatic environment near an electrode surface, triggering the assembly and disassembly of biomolecules.
520 $a This thesis describes four major contributions towards the development of bioelectronic interfaces for directed self-assembly: (1) Electronically activated F-actin polymerization. The use of low and high frequency AC voltages enables dynamic control over the formation of supramolecular actin architectures that are unprecedented in bulk experiments. (2) Electric-field controlled hybridization and melting of DNA linkers at surfaces for enhanced biosensor performance and nanoscale patterning. (3) An electrostatic model for DNA hybridization at surfaces. This theoretical treatment validates previous experimental results and can be used to optimize biosensor performance for a wide range of experimental parameters. (4) Enhancement of DNA hybridization to surface-immobilized peptide nucleic acid (PNA) probes.
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