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Agnostic tracking: Nanoscale, high b...

Desai, Kalpit V.

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Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology./
Author:	Desai, Kalpit V.
Description:	147 p.
Notes:	Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1761.
Contained By:	Dissertation Abstracts International69-03B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3294235
ISBN:	9780549558415

Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology.
Desai, Kalpit V.

Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology. - 147 p.

Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1761.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2007.

The ability to detect biological events at single molecule level provides unique insights in the field of biophysics. Back-focal-plane laser interferometry is a promising technique for single-molecule-scale, 3D position measurements at rates far beyond the capability of video. I present an in-situ calibration method for the back-focal-plane, low-power (non-trapping) laser interferometry. The software-based technique does not rely on any a priori model or calibration knowledge; hence the name Agnostic. The technique is sufficiently fast and non-invasive that the calibration can be performed on the fly, without interrupting or compromising the on-going experiment. The technique can be applied to track 3D, long range motion (up to 100 um) of a broad variety of microscopic biological objects. The spatiotemporal resolution achieved is of the order of a few nanometers and tens of microseconds.

ISBN: 9780549558415Subjects--Topical Terms:

1017686
Biology, Cell.

Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology.
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100 1 $a Desai, Kalpit V. $3 1674647
245 1 0 $a Agnostic tracking: Nanoscale, high bandwidth, three-dimensional particle tracking for biology.
300 $a 147 p.
500 $a Source: Dissertation Abstracts International, Volume: 69-03, Section: B, page: 1761.
500 $a Advisers: T. Gary Bishop; Carol Lucas.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2007.
520 $a The ability to detect biological events at single molecule level provides unique insights in the field of biophysics. Back-focal-plane laser interferometry is a promising technique for single-molecule-scale, 3D position measurements at rates far beyond the capability of video. I present an in-situ calibration method for the back-focal-plane, low-power (non-trapping) laser interferometry. The software-based technique does not rely on any a priori model or calibration knowledge; hence the name Agnostic. The technique is sufficiently fast and non-invasive that the calibration can be performed on the fly, without interrupting or compromising the on-going experiment. The technique can be applied to track 3D, long range motion (up to 100 um) of a broad variety of microscopic biological objects. The spatiotemporal resolution achieved is of the order of a few nanometers and tens of microseconds.
520 $a Three biological applications enabled by the technique are presented: firstly, a prototype of an oscillating-bead high-bandwidth frequency-response analyzer for biology, based on Agnostic Tracking as implemented in our custom-built 3D Magnetic Force Microscope (3DFM); secondly, a magnetic-force study that revealed a previously-unknown anchoring-dependent nonlinear response of a cellular membrane; last, a rheological study that revealed a novel grouping of motion characteristics of individual vesicles diffusing inside live cytoplasm.
590 $a School code: 0153.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biophysics, General. $3 1019105
690 $a 0379
690 $a 0541
690 $a 0786
710 2 $a The University of North Carolina at Chapel Hill. $b Biomedical Engineering Joint Program. $3 1043311
773 0 $t Dissertation Abstracts International $g 69-03B.
790 1 0 $a Bishop, T. Gary, $e advisor
790 1 0 $a Lucas, Carol, $e advisor
790 $a 0153
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3294235