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Motion of nano-objects in Langmuir m...

Forstner, Martin Bernhard.

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Motion of nano-objects in Langmuir monolayers.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Motion of nano-objects in Langmuir monolayers./
作者:	Forstner, Martin Bernhard.
面頁冊數:	172 p.
附註:	Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0117.
Contained By:	Dissertation Abstracts International65-01B.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3119640
ISBN:	9780496670291

Motion of nano-objects in Langmuir monolayers.
Forstner, Martin Bernhard.

Motion of nano-objects in Langmuir monolayers. - 172 p.

Source: Dissertation Abstracts International, Volume: 65-01, Section: B, page: 0117.

Thesis (Ph.D.)--The University of Texas at Austin, 2003.

In today's biological membrane research there are several unresolved inconsistencies. First, diffusion of the same molecules within biological membranes is found to be slower than their diffusion in model membranes by a factor of up to 10. Second, although based on partially insufficient data, deviations from normal diffusion, such as anomalous subdiffusion, have been reported. It is assumed that the spatial organization of membranes plays a key role in these changes in diffusive motion. However, the underlying physical principles that govern the relation between membrane structure and diffusion are not understood.

ISBN: 9780496670291Subjects--Topical Terms:

1019105
Biophysics, General.

Motion of nano-objects in Langmuir monolayers.
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500 $a Supervisors: Josef Kas; Harry Swinney.
502 $a Thesis (Ph.D.)--The University of Texas at Austin, 2003.
520 $a In today's biological membrane research there are several unresolved inconsistencies. First, diffusion of the same molecules within biological membranes is found to be slower than their diffusion in model membranes by a factor of up to 10. Second, although based on partially insufficient data, deviations from normal diffusion, such as anomalous subdiffusion, have been reported. It is assumed that the spatial organization of membranes plays a key role in these changes in diffusive motion. However, the underlying physical principles that govern the relation between membrane structure and diffusion are not understood.
520 $a The systematic study of these problems requires the use of new methods that probe diffusion on the nanometer scale of individual diffusive particles, in well defined membrane model systems. To meet this necessity we have developed two new techniques. The first tracks the motion of gold labeled lipids in homogeneous lipid monolayers. Our investigations show that the diffusion in this system is normal over almost three decades in time and the obtained diffusion coefficients are consistent with those previously obtained using ensemble methods. Our second method uses fluorescent beads 100 nm in diameter that are imbedded in inhomogeneous DMPE (1,2-dimyristoyl-sn-glycero-2-phosphoethanolamine) monolayers. This method is capable of simultaneously imaging the motion of the particle and the monolayer structure. This permits the detailed study of the impact of membrane structures on diffusive behavior. We find that pure obstruction does not lead to a change in diffusive behavior. However, more complex interactions, such as dipole-dipole interactions, between domains and diffusive probe can lead to transitions between regimes of normal diffusion with different diffusion coefficients on different time and length scales.
520 $a Although the membrane models used are simple compared with real cell membranes, they show that interactions between membrane structures and diffusing moieties can determine diffusive speed. Such mechanisms would be sufficient for the cell to regulate functions that rely on diffusion within the membrane. An example for such a task is intracellular signaling. Its proper functioning could be severely impacted by changes in membrane morphology as they occur for example, during Alzheimer's disease.
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