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MicroRNA machinery as an integral co...

Carpio, Lawrence L.

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MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy./
作者:	Carpio, Lawrence L.
面頁冊數:	73 p.
附註:	Source: Masters Abstracts International, Volume: 48-03, page: 1523.
Contained By:	Masters Abstracts International48-03.
標題:	Biology, Virology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1473529
ISBN:	9781109567373

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.
Carpio, Lawrence L.

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy. - 73 p.

Source: Masters Abstracts International, Volume: 48-03, page: 1523.

Thesis (M.S.)--The George Washington University, 2010.

Human immunodeficiency virus is the foremost cause of acquired immunodeficiency syndrome. The current treatments do not focus on how in latent cells, the virus could still mutate. A drug resistant virus within the host will eventually lead to AIDS. Researchers must gain an appreciation of how latent cells function to keep the virus alive and away from immune response. In recent findings, the ability of HIV-1 to create its own viral microRNA from the TAR hairpin element is important for manipulating host cell mechanisms and maintaining latency. HIV-1 manipulates host cell mechanisms, such as cyclin dependent kinases and their corresponding cyclin elements, to suppress apoptotic cellular pathways and to maintain a latent infection. The therapeutic focus now turns to developing effective cdk inhibitors that eliminate viral replication, but do not affect normal cellular mechanisms. To do this, researchers need to understand the importance of how RNAi plays a role in viral activation and drug efficacy. A thorough understanding of HIV-1 microRNA pathways and latency could lead to alternative treatment options for HIV-1 infection.

ISBN: 9781109567373Subjects--Topical Terms:

1019068
Biology, Virology.

MicroRNA machinery as an integral component of viral transcription mechanisms and drug efficacy.
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