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Analysis of regulatory T cell activa...

Lockett, Nikki Nikkia.

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Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy./
Author:	Lockett, Nikki Nikkia.
Description:	71 p.
Notes:	Source: Masters Abstracts International, Volume: 48-02, page: 0908.
Contained By:	Masters Abstracts International48-02.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1470499
ISBN:	9781109516043

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.
Lockett, Nikki Nikkia.

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy. - 71 p.

Source: Masters Abstracts International, Volume: 48-02, page: 0908.

Thesis (M.S.)--Mississippi State University, 2009.

Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 and CTLA4 was decreased at early gestation in FIV-infected queens and a trend toward decreased expression of CD25, FOXP3, and CTLA4 in placentas from FIV-infected queens producing non-viable pregnancies was observed as well. Our results suggest that FIV infection may alter placental Treg function and adversely affect pregnancy outcome.

ISBN: 9781109516043Subjects--Topical Terms:

1017734
Biology, Microbiology.

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.
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020 $a 9781109516043
035 $a (UMI)AAI1470499
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040 $a UMI $c UMI
100 1 $a Lockett, Nikki Nikkia. $3 1669100
245 1 0 $a Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.
300 $a 71 p.
500 $a Source: Masters Abstracts International, Volume: 48-02, page: 0908.
500 $a Adviser: Karen Coats.
502 $a Thesis (M.S.)--Mississippi State University, 2009.
520 $a Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 and CTLA4 was decreased at early gestation in FIV-infected queens and a trend toward decreased expression of CD25, FOXP3, and CTLA4 in placentas from FIV-infected queens producing non-viable pregnancies was observed as well. Our results suggest that FIV infection may alter placental Treg function and adversely affect pregnancy outcome.
590 $a School code: 0132.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Virology. $3 1019068
650 4 $a Biology, Veterinary Science. $3 1021733
690 $a 0410
690 $a 0720
690 $a 0778
710 2 $a Mississippi State University. $b Biological Sciences. $3 1669101
773 0 $t Masters Abstracts International $g 48-02.
790 1 0 $a Coats, Karen, $e advisor
790 1 0 $a Wise, Dwayne $e committee member
790 1 0 $a Pharr, Gregory $e committee member
790 $a 0132
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1470499