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Analysis of regulatory T cell activa...

Lockett, Nikki Nikkia.

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Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy./
作者:	Lockett, Nikki Nikkia.
面頁冊數:	71 p.
附註:	Source: Masters Abstracts International, Volume: 48-02, page: 0908.
Contained By:	Masters Abstracts International48-02.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1470499
ISBN:	9781109516043

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.
Lockett, Nikki Nikkia.

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy. - 71 p.

Source: Masters Abstracts International, Volume: 48-02, page: 0908.

Thesis (M.S.)--Mississippi State University, 2009.

Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 and CTLA4 was decreased at early gestation in FIV-infected queens and a trend toward decreased expression of CD25, FOXP3, and CTLA4 in placentas from FIV-infected queens producing non-viable pregnancies was observed as well. Our results suggest that FIV infection may alter placental Treg function and adversely affect pregnancy outcome.

ISBN: 9781109516043Subjects--Topical Terms:

1017734
Biology, Microbiology.

Analysis of regulatory T cell activation markers in feline immunodeficiency virus (FIV)-infected and control placenta samples from early and late term pregnancy.
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520 $a Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 and CTLA4 was decreased at early gestation in FIV-infected queens and a trend toward decreased expression of CD25, FOXP3, and CTLA4 in placentas from FIV-infected queens producing non-viable pregnancies was observed as well. Our results suggest that FIV infection may alter placental Treg function and adversely affect pregnancy outcome.
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