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Construction of a dual infection mec...
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Piekarski, Joseph Matthew.
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Construction of a dual infection mechanism for HIV.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Construction of a dual infection mechanism for HIV./
作者:
Piekarski, Joseph Matthew.
面頁冊數:
148 p.
附註:
Source: Masters Abstracts International, Volume: 47-06, page: 3444.
Contained By:
Masters Abstracts International47-06.
標題:
Biology, Virology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465379
ISBN:
9781109187526
Construction of a dual infection mechanism for HIV.
Piekarski, Joseph Matthew.
Construction of a dual infection mechanism for HIV.
- 148 p.
Source: Masters Abstracts International, Volume: 47-06, page: 3444.
Thesis (M.S.)--University of Maryland, Baltimore County, 2009.
In this work, we created three mathematical models to describe HIV infection. Our goal was to investigate the effectiveness of cell-to-cell infection via "virological synapses" through the designed models. The combination of cell-to-cell infection and free-floating virus mechanisms in mathematical models has not been investigated as of yet. We evaluated the two models using three statistical techniques, and decided to use a weighted summation of squares to compare our projected results to published experimental data. The analysis found that the addition of a cell-to-cell infection mechanism did not hinder the predictability of HIV markers for disease progression and showed cell-to-cell infection was most significant early on in infection. In our last model, we further investigated the mechanisms responsible for T cell depletion. Many theories have been published hypothesizing the cause of immune failure. These range from heightened activation of T cells, cytotoxic virions and the eventual destruction due to productive infection. In our model, we observed that the majority of cells die due to the direct result of infection.
ISBN: 9781109187526Subjects--Topical Terms:
1019068
Biology, Virology.
Construction of a dual infection mechanism for HIV.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1465379
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