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Aerobic glycolysis: A novel signatur...

Benton, Geoffrey Marsing.

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Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue./
Author:	Benton, Geoffrey Marsing.
Description:	83 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0739.
Contained By:	Dissertation Abstracts International71-02B.
Subject:	Biology, Cell. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3390032
ISBN:	9781109578096

Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue.
Benton, Geoffrey Marsing.

Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue. - 83 p.

Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0739.

Thesis (Ph.D.)--University of California, San Francisco, 2010.

It is well established that tumors exhibit abnormal aerobic glycolysis, a metabolic alteration known as "Warburg effect". However, it is unclear whether this phenotype reflects a metabolic shift during carcinogenesis or alternatively is a pre-existing event. In the present dissertation, we establish that a variant subpopulation of primary, non-transformed human mammary epithelial cells (vHMEC) shares this aerobic glycolysis signature with cancer cell lines. This phenotype is characterized by an increase in lactate production and synthesis as a result of lactate dehydrogenase (LDH) upregulation and is modulated by both hypoxia-induced factor HIF-1alpha and AKT. Strikingly, simultaneous over-expression of COX-2 and LDHA can be detected in morphologically normal epithelial cells in disease-free breast tissue, supporting that aerobic glycolysis pre-exists in vivo prior to carcinogenesis. Furthermore, we demonstrate that the lactate accumulation occurring in vHMEC can be readily detected by magnetic resonance spectroscopy (MRS), suggesting that aerobic glycolysis can be monitored in vivo. These novel findings further our understanding of pre-malignant events and could potentially lead to dramatic improvements in non-invasive detection of premalignant lesions in breast cancer patients.

ISBN: 9781109578096Subjects--Topical Terms:

1017686
Biology, Cell.

Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue.
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035 $a (UMI)AAI3390032
035 $a AAI3390032
040 $a UMI $c UMI
100 1 $a Benton, Geoffrey Marsing. $3 1669031
245 1 0 $a Aerobic glycolysis: A novel signature of premalignancy in disease-free breast tissue.
300 $a 83 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-02, Section: B, page: 0739.
500 $a Adviser: Thea D. Tlsty.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2010.
520 $a It is well established that tumors exhibit abnormal aerobic glycolysis, a metabolic alteration known as "Warburg effect". However, it is unclear whether this phenotype reflects a metabolic shift during carcinogenesis or alternatively is a pre-existing event. In the present dissertation, we establish that a variant subpopulation of primary, non-transformed human mammary epithelial cells (vHMEC) shares this aerobic glycolysis signature with cancer cell lines. This phenotype is characterized by an increase in lactate production and synthesis as a result of lactate dehydrogenase (LDH) upregulation and is modulated by both hypoxia-induced factor HIF-1alpha and AKT. Strikingly, simultaneous over-expression of COX-2 and LDHA can be detected in morphologically normal epithelial cells in disease-free breast tissue, supporting that aerobic glycolysis pre-exists in vivo prior to carcinogenesis. Furthermore, we demonstrate that the lactate accumulation occurring in vHMEC can be readily detected by magnetic resonance spectroscopy (MRS), suggesting that aerobic glycolysis can be monitored in vivo. These novel findings further our understanding of pre-malignant events and could potentially lead to dramatic improvements in non-invasive detection of premalignant lesions in breast cancer patients.
590 $a School code: 0034.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0379
690 $a 0992
710 2 $a University of California, San Francisco. $b Cell Biology. $3 1669032
773 0 $t Dissertation Abstracts International $g 71-02B.
790 1 0 $a Tlsty, Thea D., $e advisor
790 1 0 $a Kenyon, Cynthia $e committee member
790 1 0 $a Stokoe, David $e committee member
790 $a 0034
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3390032