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  • The practice of medicinal chemistry
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: The practice of medicinal chemistry/ edited by Camille G. Wermuth.{me_controlnum}
    其他作者: Wermuth, C. G.
    出版者: Amsterdam ;Academic Press, : 2003.,
    面頁冊數: 1 online resource (xiv, 768 p.) :ill.
    內容註: Foreward. -- Preface. -- A Brief History Of Drugs -- From Plant Extracts To DNA Technology -- Medicinal Chemistry: Definition And Objectives, The Three Main Phases Of Drug Activity, Drug And Diseases Classifications -- Measurement And Expression Of Drug Effects -- Drug Targets: Molecular Mechanisms Of Drug Action -- Strategies In The Search For New Lead Compounds Or Original Working Hypotheses -- Natural Products As Pharmaceuticals And Sources For Lead Structures -- Basics Of Combinatorial Chemistry -- The Contribution Of Molecular Biology To Drug Discovery -- Electronic Screening: Lead Finding From Database Mining -- High-Speed Chemistry Libraries: Assessment Of Drug-Likeness -- Web Alert Using The Internet For Medicinal Chemistry -- Molecular Variations In Homologous Series: Vinylogues And Benzologues -- Molecular Variations Based On Isosteric Replacements -- Ring Transformations -- Introduction Of Conformational Restriction And/Or Steric Hindrance -- Identical And Non Identical Twin Drugs -- Optical Isomerism In Drugs -- Application Strategies For The Primary Structure-Activity Relationship Exploration -- Specific Substituent Groups -- The Role Of Functional Groups In Drug-Receptor Interactions -- Compound Properties And Drug Quality -- Quantitative Approaches To Structure-Activity Relationships -- Structural Aspects Of Drug Action I -- Pharmacophore Identification And Receptor Mapping -- Three-Dimentional Quantitative Structure-Property Relationships -- Protein Crystallography And Drug Discovery -- Protein Comparative Modelling And Drug Discovery -- The Transition From Agonist To Antagonist Activity: Symmetry And Other Considerations -- Design Of Peptidomimetics -- The Fate Of Xenobiotics In Living Organisms -- Biotransformation Reactions -- Chemical Mechanisms Of Toxicity -- Basic Knowledge For Designing Safer Drugs -- Designing Prodrugs And Bioprecursors -- Macromolecular Carriers For Drug Targeting -- Preparation Of Water Soluble Compounds Through Salt Formation -- Preparation Of Water-Soluble Compounds By Covalent Attachment Of Solubilizing Moieties -- Drug Solubilization With Organic Solvents, Surfactants And Lipids -- Improvement Of Drug Properties By Cyclodextrins -- Chemical And Physicochemical Solutions To Formulation Problems -- Discover A Drug Substance, Formulate And Develop It To A Product -- Drug Nomenclature -- Legal Aspects Of Product Protection -- The Consumption And Production Of Pharmaceuticals.
    標題: Pharmaceutical chemistry. -
    電子資源: http://www.sciencedirect.com/science/book/9780127444819
    ISBN: 9780127444819
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W9149011 電子資源 11.線上閱覽_V 電子書 EB RS403 .P68 2003eb 一般使用(Normal) 在架 0
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