東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Advances in medicinal chemistry.. Vo...

Maryanoff, B. E.

FindBook

Google Book

Amazon

博客來

Advances in medicinal chemistry.. Volume 4

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Advances in medicinal chemistry./
其他作者:	Maryanoff, B. E.
出版者:	[S.l.] :Elsevier Science, : 1999.,
面頁冊數:	1 v.
內容註:	Preface. Novel peptide mimetic building blocks and strategies for efficient lead finding. Recent advances in the medicinal chemistry of taxoid anticancer agents. Synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin. Design of compound libraries for detecting and pursuing novel small molecule leads. A theoretical model of the human thrombin receptor (PAR-1), the first known protease-activated G-protein-coupled receptor. Farnesyl transferase inhibitors: design of a new class of cancer chemotherapeutic agents.
標題:	Pharmaceutical chemistry. -
電子資源:	http://www.sciencedirect.com/science/book/9780762300648
ISBN:	9780762300648

Advances in medicinal chemistry.. Volume 4
Advances in medicinal chemistry.Volume 4[electronic resource].{me_controlnum} - [S.l.] :Elsevier Science,1999. - 1 v.

Preface. Novel peptide mimetic building blocks and strategies for efficient lead finding. Recent advances in the medicinal chemistry of taxoid anticancer agents. Synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin. Design of compound libraries for detecting and pursuing novel small molecule leads. A theoretical model of the human thrombin receptor (PAR-1), the first known protease-activated G-protein-coupled receptor. Farnesyl transferase inhibitors: design of a new class of cancer chemotherapeutic agents.

Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol� (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2007.

Mode of access: World Wide Web.

ISBN: 9780762300648

Source: 122678:127510Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

550956
Pharmaceutical chemistry.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RS400 / .A35eb v. 4

Dewey Class. No.: 615/.19

Advances in medicinal chemistry.. Volume 4
LDR:02933cmm 2200301Ia 4500 001 1033732
003 OCoLC
005 20110615082934.0
006 m d
007 cr cn|||||||||
008 120420s1999 xx o 000 0 eng d
020 $a 9780762300648
020 $a 0762300647
029 1 $a NZ1 $b 12433807
035 $a (OCoLC)166344357
035 $a ocn166344357
037 $a 122678:127510 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $c OPELS $d OPELS
049 $a TEFA
050 1 4 $a RS400 $b .A35eb v. 4
082 0 4 $a 615/.19 $2 22
245 0 0 $a Advances in medicinal chemistry. $n Volume 4 $h [electronic resource].{me_controlnum}
260 $a [S.l.] : $b Elsevier Science, $c 1999.
300 $a 1 v.
505 0 $a Preface. Novel peptide mimetic building blocks and strategies for efficient lead finding. Recent advances in the medicinal chemistry of taxoid anticancer agents. Synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin. Design of compound libraries for detecting and pursuing novel small molecule leads. A theoretical model of the human thrombin receptor (PAR-1), the first known protease-activated G-protein-coupled receptor. Farnesyl transferase inhibitors: design of a new class of cancer chemotherapeutic agents.
520 $a Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol� (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2007. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Aug. 15, 2007). $n Access may be restricted to users at subscribing institutions.
650 0 $a Pharmaceutical chemistry. $3 550956
655 7 $a Electronic books. $2 lcsh $3 542853
700 1 $a Maryanoff, B. E. $3 1364794
700 1 $a Reitz, A. B. $3 1364795
710 2 $a ScienceDirect (Online service) $3 848416
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780762300648
994 $a C0 $b TEF