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I. Introduction -- 1. General Introduction: Restless Legs Syndrome as a Neurological Conundrum / Werner Poewe -- 2. Introduction: The Patient's Perspective / Robert Balkam -- 3. From 1685 to 2008: An Introduction to the Restless Legs Syndrome / Allison Chan and Christian Guilleminault -- 4. Introduction: Restless Legs Syndrome as a Movement Disorder / Stanley Fahn -- 5. Restless Legs Syndrome and Nocturnal Myoclonus (Periodic Limb Movements during Sleep): An Historical Review / Elio Lugaresi and Federica Provini -- 6. Introduction: Clinical Science of Restless Legs Syndrome / Sudhansu Chokroverty -- II. Basic Science of Restless Legs Syndrome -- A. Epidemiology and Genetics -- 7. The Epidemiology of Restless Legs Syndrome / Klaus Berger and Tobias Kurth -- 8. Genetics of Restless Legs Syndrome / Lan Xiong, Gustavo Turecki, Anastasia Levchenko, Claudia Gaspar, Wayne A. Hening, Jacques Montplaisir, Guy A. Rouleau -- B. Pathophysiology -- 9. The Iron Metabolic System / Stacey L. Clardy, James R. Connor, and John Beard -- 10. Iron Dysregulation in Restless Legs Syndrome / Christopher J. Earley -- 11. The Brain's Dopamine Systems and their Relevance to Restless Legs Syndrome / A.A. Freeman and D.B. Rye -- 12. Neuroimaging in Restless Legs Syndrome / Claudia Trenkwalder and Christopher J. Earley -- 13. Circadian Rhythm of Restless Legs Syndrome / Diego Garcia-Borreguero and Wayne A. Hening -- 14. Spinal Cord, Dopamine, Opiates and Restless Legs Syndrome / W. Paulus and E.D. Schomburg -- III. Clinical Science of RLS -- A. Diagnosis -- 15. Diagnosis of Restless Legs Syndrome / Richard P. Allen -- 16. Differential Diagnosis of Restless Legs Syndrome / Sudhansu Chokroverty -- 17. Periodic Limb Movements in Sleep (PLMS) / Federica Provini, Roberto Vetrugno, Pasquale Montagna, and Raffaele Ferri -- 18. Sleep Laboratory Diagnosis of Restless Legs Syndrome / Jacques Montplaisir, Martin Michaud, Marie-Hlne Pennestri, and Paola Lanfranchi -- 19. Actigraph Assessment of Periodic Leg Movements (PLM) and Restless Legs Syndrome (RLS) / Richard P. Allen and Wayne A. Hening -- 20. Assessment of Restless Legs Syndrome Features with Standardized Methods / Heike Benes and Ralf Kohnen -- B. Co-Morbidities and Special Populations -- 21. Restless Legs Syndrome and Periodic Limb Movement Disorder in Childhood and Adolescence / Daniel L. Picchietti and Arthur S. Walters -- 22. Restless Legs Syndrome and Pregnancy / Mauro Manconi and Luigi Ferini-Strambi -- 23. Restless Legs Syndrome and Periodic Limb Movements in the Elderly with and without Dementia / Donald L. Bliwise -- 24. Restless Legs Syndrome in Medical Disorders / John W. Winkelman and Jan Ulfberg -- 25. Restless Legs Syndrome in Neurological Disorders / William Ondo and Michael Polydefkis -- 26. Is the Manifestation of the Restless Legs Syndrome Related to a Pain Mechanism? / Dan�ile Laverdure-Dupont, Gilles Lavigne, Jacques Montplaisir, and Peter Soja -- 27. Restless Legs Syndrome and Psychiatric Disorders / Hochang Ben Lee and Wayne A. Hening -- C. Management -- 28. Overview of Management / Wayne A. Hening -- 29. Non-Pharmacologic Considerations and Treatment of Restless Legs Syndrome / Mark J. Buchfuhrer and Jill Gunzel -- 30. Dopaminergic Therapy of Restless Legs Syndrome / Michael H. Silber and Richard P. Allen -- 31. Opioid Agents in the Treatment of Restless Legs Syndrome / Phillip M. Becker -- 32. The Use of Anti-convulsants in Treatment of Restless Legs Syndrome / Diego Garcia-Borreguero and Mark Buchfuhrer -- 33. Iron Treatment / Christopher J. Earley -- 34. Additional Agents and Miscellaneous Therapies / Mark Buchfuhrer and Wayne Hening -- 35. Management of Restless Legs Syndrome in Hospital and during Surgery / Birgit Hogl and Viola Gschliesser -- 36. Restless Legs Syndrome Morbidity: Sleep and Quality of Life / Richard P. Allen, Heike Benes, and Ralf Kohnen -- 37. History of the Restless Legs Syndrome Foundation / Georgianna Bell and Pickett Guthrie -- Summary / Wayne A. Hening. |