-- Preface. -- Part I: Introduction to free radicals. -- Free radical chemistry. -- Part II: Reactive species in tissues. -- Exercise and oxygen radical production by muscle. -- Exercise and xanthine oxidase in the vasculature: -- superoxide and nitric oxide interactions. -- Part III: Oxidative stress: Mechanisms and manifestations. -- Chemical bases and biological relevance of protein oxidation. -- Oxidative DNA damage in exercise. -- Part IV: Antioxidant defenses. -- Physiological antioxidants and exercise training. -- Antioxidants and physical exercise. -- Part V: Nutrition. -- Dietary sources and bioavailability of essential and nonessential -- antioxidants. -- Vitamin E. -- Part VI: Cellular and molecular mechanisms. -- Biological thiols and redox regulation of cellular induced signaling. -- Regulation and deregulation of vascular smooth muscle cells by -- reactive oxygen species and by &agr;-tocopherol. -- Part VII: Analytical methods. -- Oxidative stress indices: analytical aspects and significance. -- Noninvasive measures of muscle metabolism. -- Part VIII: Environmental factors. -- Air pollution and oxidative stress. -- Oxidants in skin pathophysiology. -- Part IX: Organ functions. -- Muscle fatigue: mechanisms and regulation. -- Influence of exercise-induced oxidative stress on the -- central nervous system. -- Part X: Aging. -- Oxidants and aging. -- Molecular mechanisms of oxidative stress in aging: free radicals, -- aging, antioxidants and disease. -- Part XI: Disease processes. -- Oxidative stress, antioxidants and cancer. -- Hypoxia, oxidative stress and exercise in rheumatoid arthritis. -- Index of authors. -- Subject index.