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Ultrasound backscatter microscopy an...

Sherar, Michael David.

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Ultrasound backscatter microscopy and its application to biological studies.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Ultrasound backscatter microscopy and its application to biological studies./
Author:	Sherar, Michael David.
Description:	144 p.
Notes:	Source: Dissertation Abstracts International, Volume: 52-11, Section: B, page: 5713.
Contained By:	Dissertation Abstracts International52-11B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN59974
ISBN:	9780315599741

Ultrasound backscatter microscopy and its application to biological studies.
Sherar, Michael David.

Ultrasound backscatter microscopy and its application to biological studies. - 144 p.

Source: Dissertation Abstracts International, Volume: 52-11, Section: B, page: 5713.

Thesis (Ph.D.)--University of Toronto (Canada), 1990.

Ultrasound microscopy uses high frequency acoustic waves ($\geq

ISBN: 9780315599741Subjects--Topical Terms:

1017681
Biophysics, Medical.

Ultrasound backscatter microscopy and its application to biological studies.
LDR:03549nam 2200301 a 45 001 973263
005 20110928
008 110928s1990 eng d
020 $a 9780315599741
035 $a (UMI)AAINN59974
035 $a AAINN59974
040 $a UMI $c UMI
100 1 $a Sherar, Michael David. $3 1297217
245 1 0 $a Ultrasound backscatter microscopy and its application to biological studies.
300 $a 144 p.
500 $a Source: Dissertation Abstracts International, Volume: 52-11, Section: B, page: 5713.
500 $a Supervisor: S. Foster.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 1990.
520 $a Ultrasound microscopy uses high frequency acoustic waves ($\geq $5 0 MHz) to probe the elastic structure of specimens on a microscopic scale. These instruments have been applied to the analysis of solid materials but are not used extensively in biological and medical science. This is because conventional ultrasound microscopes rely on the transmission of ultrasound through a biological specimen resulting in a simple shadowgram. This approach demonstrates little advantage over optical microscopy techniques. However, ultrasound does have unique advantages for use in microscopy of biological specimens which have not been fully exploited. Firstly, ultrasound can penetrate through the specimen and secondly it is a non-ionising form of radiation. These properties offer the possibility of imaging at depth in living specimens.
520 $a Pulse-echo methods, which rely on the detection of ultrasound scattered in the specimen, have been used in a great variety of clinical scanners operating in the 1 MHz to 20 MHz range. These scanners have had considerable success monitoring pregnancies and diagnosing disease deep in the body without the risk associated with ionising radiation. The extension of pulse-echo methods to higher frequencies offers the opportunity for non-invasive imaging on a microscopic scale.
520 $a In this thesis, I describe the extension of pulse-echo techniques into the microscopy domain with the development of 100 MHz ultrasound backscatter microscopes. This has required the development of high frequency transducers with sufficient sensitivity to detect small ultrasound backscatter signals and sufficient bandwidth to give good axial resolution in the images. Initially the images were acquired on a point by point basis (C-scan). The resolution achieved was approximately 20 $\mu $m and tomographic images could be produced at a maximum depth of about 3 mm to 4 mm in the specimen. This microscope was applied to imaging spheroids as well as intact ocular tissue, demonstrating the technique is very sensitive to changes in tissue structure.
520 $a Unfortunately, the C-scan method requires approximately 10 minutes to acquire one image. This led us to develop a more practical "real time" (B-scan) 100- MHz microscope which can produce images at a rate of 5 frames/sec. We have applied this microscope to imaging spheroids and ocular tissue, producing images which show good delineation of tissue structure. The images suggest that ultrasound backscatter microscopy may have several clinical applications. More generally, this technique could be of use in biological studies where a non-invasive method of imaging at depth is required.
590 $a School code: 0779.
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0760
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Dissertation Abstracts International $g 52-11B.
790 $a 0779
790 1 0 $a Foster, S., $e advisor
791 $a Ph.D.
792 $a 1990
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NN59974