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A shuttered probe with in-line flowm...

Papageorgiou, Demetrios Philip.

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A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery./
Author:	Papageorgiou, Demetrios Philip.
Description:	147 p.
Notes:	Chair: Kensall D. Wise.
Contained By:	Dissertation Abstracts International62-10B.
Subject:	Engineering, Electronics and Electrical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3029411
ISBN:	9780493417882

A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery.
Papageorgiou, Demetrios Philip.

A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery. - 147 p.

Chair: Kensall D. Wise.

Thesis (Ph.D.)--University of Michigan, 2001.

A shutter has been developed which requires no additional masking or processing steps and only drops 8% (44Torr) of the injection pressure. This shutter reduces unintended delivery of fluid by approximately 25 times.

ISBN: 9780493417882Subjects--Topical Terms:

626636
Engineering, Electronics and Electrical.

A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery.
LDR:03306nam 2200337 a 45 001 971776
005 20110927
008 110927s2001 eng d
020 $a 9780493417882
035 $a (UnM)AAI3029411
035 $a AAI3029411
040 $a UnM $c UnM
100 1 $a Papageorgiou, Demetrios Philip. $3 1295806
245 1 2 $a A shuttered probe with in-line flowmeters for chronic in-vivo drug delivery.
300 $a 147 p.
500 $a Chair: Kensall D. Wise.
500 $a Source: Dissertation Abstracts International, Volume: 62-10, Section: B, page: 4697.
502 $a Thesis (Ph.D.)--University of Michigan, 2001.
520 $a A shutter has been developed which requires no additional masking or processing steps and only drops 8% (44Torr) of the injection pressure. This shutter reduces unintended delivery of fluid by approximately 25 times.
520 $a Determining the electrical response of a neural network to acoustical, electrical, or other types of stimulation is a topic of great interest. The use of drugs to alter the chemical environment of neurons is vital for further insight into the workings of the nervous system. Implied in this function is the use of chemical delivery systems to control fluid in terms of quantity and time. Many of the necessary components for pico-liter level chemical delivery are described in this thesis.
520 $a The focus of this research includes process improvements to the existing chemical delivery probes as well as the development of process-compatible shutters for limiting unwanted chemical delivery, flowmeters for confirmation and quantification of the flow, pumps and valves for the control of fluid movement, and integrated flexible interconnects to connect the probe to a reservoir. These process improvements include altering the trench shape from chevrons to slashes, increasing the spacing between trenches, use of a new contact process.
520 $a An integrated flowmeter has been developed which requires only two extra masking steps. This hot-wire anemometer rests on a dielectric window and is capped with an air chamber. The flow resolution is better than 50pL/sec and can be improved to about 9pL/sec with on-chip circuitry.
520 $a The final step in controlling drug delivery is the incorporation of pumps and valves. A 70mum-radius thermopneumatic device actuated using the phase-change of a low-boiling-point liquid (cyclopentane) requires only 7mW to close the valve in 100musec. A pumping cycle implemented using a three-valve peristaltic pump can deliver 3pL of fluid while raising the surrounding temperature by less than 0.5°C.
520 $a The addition of integrated fluidic cables can provide flexible multi-channel tubing. These fluidic cables can be realized with no additional masking steps. This fluidic interconnect is almost twice as flexible as polyimide tubing. Together, all these components provide a foundation for realizing minimally-invasive, chronically-implantable chemical delivery systems needed for research at the cellular level.
590 $a School code: 0127.
650 4 $a Engineering, Electronics and Electrical. $3 626636
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0544
690 $a 0572
710 2 0 $a University of Michigan. $3 777416
773 0 $t Dissertation Abstracts International $g 62-10B.
790 $a 0127
790 1 0 $a Wise, Kensall D., $e advisor
791 $a Ph.D.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3029411