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Exploring mechanisms for circadian p...

Bullough, John Donovan.

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Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum./
Author:	Bullough, John Donovan.
Description:	131 p.
Notes:	Adviser: Robert H. Parsons.
Contained By:	Dissertation Abstracts International65-02B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122976
ISBN:	9780496702909

Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum.
Bullough, John Donovan.

Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum. - 131 p.

Adviser: Robert H. Parsons.

Thesis (Ph.D.)--Rensselaer Polytechnic Institute, 2004.

Like all living organisms, domestic mice (Mus musculus) exhibit regular, nearly-24-hour (circadian) cycles of rest and activity, even in the presence of continuous darkness. Ocular exposure to light can advance (cause to occur earlier) or delay (cause to occur later) locomotor activity, depending upon the time of day light is provided. Using phase delay of the locomotor activity rhythm as a measure of the impact of light on the circadian system of Mus musculus, animals were exposed to various irradiances (&sim;1 to 20 muW/cm2) at three different wavelengths (350, 470 and 525 nm: 350 nm from ultraviolet fluorescent lamps; 470 and 525 nm from light emitting diodes), individually and in combination. The responses, as well as the known physiology of Mus musculus, were consistent with a mechanism for circadian phototransduction that obeys univariance, with phase delays from combined wavelength stimuli predicted in an additive manner by the phase delays elicited by individual wavelengths. The spectral sensitivity predicted by the present data and the physiology of this species also support the role of a photosensitive retinal ganglion cell, most likely containing melanopsin, as participating in circadian phototransduction in Mus musculus.

ISBN: 9780496702909Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum.
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008 110921s2004 eng d
020 $a 9780496702909
035 $a (UMI)AAI3122976
035 $a AAI3122976
040 $a UMI $c UMI
100 1 $a Bullough, John Donovan. $3 1294800
245 1 0 $a Exploring mechanisms for circadian phototransduction in Mus musculus using light spectrum.
300 $a 131 p.
500 $a Adviser: Robert H. Parsons.
500 $a Source: Dissertation Abstracts International, Volume: 65-02, Section: B, page: 0584.
502 $a Thesis (Ph.D.)--Rensselaer Polytechnic Institute, 2004.
520 $a Like all living organisms, domestic mice (Mus musculus) exhibit regular, nearly-24-hour (circadian) cycles of rest and activity, even in the presence of continuous darkness. Ocular exposure to light can advance (cause to occur earlier) or delay (cause to occur later) locomotor activity, depending upon the time of day light is provided. Using phase delay of the locomotor activity rhythm as a measure of the impact of light on the circadian system of Mus musculus, animals were exposed to various irradiances (&sim;1 to 20 muW/cm2) at three different wavelengths (350, 470 and 525 nm: 350 nm from ultraviolet fluorescent lamps; 470 and 525 nm from light emitting diodes), individually and in combination. The responses, as well as the known physiology of Mus musculus, were consistent with a mechanism for circadian phototransduction that obeys univariance, with phase delays from combined wavelength stimuli predicted in an additive manner by the phase delays elicited by individual wavelengths. The spectral sensitivity predicted by the present data and the physiology of this species also support the role of a photosensitive retinal ganglion cell, most likely containing melanopsin, as participating in circadian phototransduction in Mus musculus.
590 $a School code: 0185.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, General. $3 1019105
690 $a 0317
690 $a 0433
690 $a 0786
710 2 0 $a Rensselaer Polytechnic Institute. $3 1019062
773 0 $t Dissertation Abstracts International $g 65-02B.
790 $a 0185
790 1 0 $a Parsons, Robert H., $e advisor
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3122976