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An assessment of vascular normalizat...

Darpolor, Moses M.

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An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging./
Author:	Darpolor, Moses M.
Description:	93 p.
Notes:	Adviser: Kristina M. Ropella.
Contained By:	Dissertation Abstracts International67-12B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3244562

An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging.
Darpolor, Moses M.

An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging. - 93 p.

Adviser: Kristina M. Ropella.

Thesis (Ph.D.)--Marquette University, 2006.

Therefore, it is suggested here that DSC-MRI measurements could play an important role for assessing vascular "normalization" of tumor and the efficacy of combining drug treatment.Subjects--Topical Terms:

1017681
Biophysics, Medical.

An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging.
LDR:03645nam 2200301 a 45 001 970681
005 20110921
008 110921s2006 eng d
035 $a (UMI)AAI3244562
035 $a AAI3244562
040 $a UMI $c UMI
100 1 $a Darpolor, Moses M. $3 1294717
245 1 3 $a An assessment of vascular normalization in 9L gliosarcoma brain tumor: Using dynamic susceptibility contrast (DSC) imaging and dynamic contrast enhancement (DCE) imaging.
300 $a 93 p.
500 $a Adviser: Kristina M. Ropella.
500 $a Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 6951.
502 $a Thesis (Ph.D.)--Marquette University, 2006.
520 $a Therefore, it is suggested here that DSC-MRI measurements could play an important role for assessing vascular "normalization" of tumor and the efficacy of combining drug treatment.
520 $a Emerging concepts and evidence have purported that certain antiangiogenic drugs can transiently "normalize" the abnormal morphology and function of tumor vasculature. It is suggested that this transitory period of vascular "normalization" is suitable for drug delivery to tumor microenvironment, and may improve the efficiency of chemotherapy or radiotherapy. From another perspective, this view seems rather counterintuitive since the normalization of tumor vasculature could potentially augment the growth rate of tumor. Understanding this process has significant implications for improving therapeutic outcomes. For if normalization provides the best time during which treatment should be administered, we want to know when the normalization occurs, and how to optimize timing, dosing and possibly the combinations of drugs administered. If normalization results in advanced tumor growth, rather than a window of opportunity, we want to make sure treatment strategies avoid normalization as an endpoint. We hypothesize that advanced physiologic imaging methods can provide the information necessary to detect and characterize "normalization" and subsequently optimize treatment strategies. DSC can provide parametric measurements such as relative cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT) which can be use to estimate the vascular morphology (i.e. micro/macro vessels) and vascular function of tumors.
520 $a Rat brain was implanted with tumor and examined on a 3 Tesla MR system by implementing DSC and DCE techniques. Cerebral perfusion (CBF/MTT) in brain tumor is quite inefficient as demonstrated by DSC. This inefficient perfusion is attributed to the density of irregularly shaped vessels in rat brain tumors as elucidate by micro-computed tomography of intact vessel tree. It is shown that the density of tortuous vessels is the prime suspect of abnormal perfusion. DSC parameters were validated by use of microscopy on brain tissues. Immunohistochemistry, anti-CD31, showed some regression in vessel size after dexamethasone therapy as possible indication of vascular "normalization". Dexamethasone treatment also reduced vascular permeability in terms of Ktrans as computed from DCE. Cerebral blood volume measure from DSC is a potential surrogate marker to characterize the "normalization" of tumor vasculatures during antiangiogenic therapy. And Temozolomide treatment in this window produced a synergistic effect.
590 $a School code: 0116.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0541
690 $a 0574
690 $a 0760
710 2 0 $a Marquette University. $3 1019299
773 0 $t Dissertation Abstracts International $g 67-12B.
790 $a 0116
790 1 0 $a Ropella, Kristina M., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3244562