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Hedgehog signaling: Its function and...

Jeong, Juhee.

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Hedgehog signaling: Its function and regulation during mouse development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Hedgehog signaling: Its function and regulation during mouse development./
Author:	Jeong, Juhee.
Description:	133 p.
Notes:	Adviser: Andrew P. McMahon.
Contained By:	Dissertation Abstracts International65-05B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131876
ISBN:	9780496791163

Hedgehog signaling: Its function and regulation during mouse development.
Jeong, Juhee.

Hedgehog signaling: Its function and regulation during mouse development. - 133 p.

Adviser: Andrew P. McMahon.

Thesis (Ph.D.)--Harvard University, 2004.

Hedgehog (Hh) family molecules are one of the most important regulators of development in many different species. I have investigated the biological function and regulatory mechanism of Hh signaling during mouse development using genetic manipulations available in this organism. In Chapter 2, I demonstrated that Hh signaling is required for formation of much of the head structures. Loss of Hh-responsiveness in neural crest cells (NCCs), which normally make up most of the face, results in impaired growth of facial primordia due to increased death and decreased proliferation of NCCs. In addition, Hh signaling regulates expression of five members of the Fox family transcription factors within the facial mesenchyme, suggesting that a Hh-Fox genetic pathway may be central to craniofacial development. In Chapter 3, I explored the role that feedback mechanisms play in shaping the response to Shh signaling in its neural target field. I provide evidence that Patched 1 (Ptc1)- and Hip1-mediated ligand-dependent feedback antagonism is responsible for tight regulation of Hh signaling during spinal cord development; removing Ptc1- and Hip1-mediated antagonism results in abnormal growth and patterning of the neural tube. Together, the work identifies new developmental functions for Hh signaling, and provides mechanistic insights into the regulatory controls governing morphogen signaling.

ISBN: 9780496791163Subjects--Topical Terms:

1017730
Biology, Genetics.

Hedgehog signaling: Its function and regulation during mouse development.
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005 20110921
008 110921s2004 eng d
020 $a 9780496791163
035 $a (UMI)AAI3131876
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040 $a UMI $c UMI
100 1 $a Jeong, Juhee. $3 1294637
245 1 0 $a Hedgehog signaling: Its function and regulation during mouse development.
300 $a 133 p.
500 $a Adviser: Andrew P. McMahon.
500 $a Source: Dissertation Abstracts International, Volume: 65-05, Section: B, page: 2216.
502 $a Thesis (Ph.D.)--Harvard University, 2004.
520 $a Hedgehog (Hh) family molecules are one of the most important regulators of development in many different species. I have investigated the biological function and regulatory mechanism of Hh signaling during mouse development using genetic manipulations available in this organism. In Chapter 2, I demonstrated that Hh signaling is required for formation of much of the head structures. Loss of Hh-responsiveness in neural crest cells (NCCs), which normally make up most of the face, results in impaired growth of facial primordia due to increased death and decreased proliferation of NCCs. In addition, Hh signaling regulates expression of five members of the Fox family transcription factors within the facial mesenchyme, suggesting that a Hh-Fox genetic pathway may be central to craniofacial development. In Chapter 3, I explored the role that feedback mechanisms play in shaping the response to Shh signaling in its neural target field. I provide evidence that Patched 1 (Ptc1)- and Hip1-mediated ligand-dependent feedback antagonism is responsible for tight regulation of Hh signaling during spinal cord development; removing Ptc1- and Hip1-mediated antagonism results in abnormal growth and patterning of the neural tube. Together, the work identifies new developmental functions for Hh signaling, and provides mechanistic insights into the regulatory controls governing morphogen signaling.
590 $a School code: 0084.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 65-05B.
790 $a 0084
790 1 0 $a McMahon, Andrew P., $e advisor
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3131876