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Initial events in the muscle atrophy...

Urso, Maria L.

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Initial events in the muscle atrophy program.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Initial events in the muscle atrophy program./
Author:	Urso, Maria L.
Description:	302 p.
Notes:	Adviser: Priscilla M. Clarkson.
Contained By:	Dissertation Abstracts International67-04B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3215767
ISBN:	9780542656712

Initial events in the muscle atrophy program.
Urso, Maria L.

Initial events in the muscle atrophy program. - 302 p.

Adviser: Priscilla M. Clarkson.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2006.

The aim of this dissertation was to explore alterations in human skeletal muscle during a controlled period of immobilization and following spinal cord injury (SCI). Study I examined the effects of an imposed period of immobilization of the adductor pollicis (AP) muscle on muscle function and volume in young (18-25 years) and aged (60-75 years) men. Muscle strength and volume of the AP was assessed before and after immobilization. Results from Study I show that although the older and younger adults had disparate losses in muscle volume they experienced similar losses in muscle strength. These results confirm that even short periods of inactivity promote more rapid losses in muscle volume in older adults, while the ability to generate force is maintained.

ISBN: 9780542656712Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Initial events in the muscle atrophy program.
LDR:03270nam 2200313 a 45 001 969144
005 20110920
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020 $a 9780542656712
035 $a (UMI)AAI3215767
035 $a AAI3215767
040 $a UMI $c UMI
100 1 $a Urso, Maria L. $3 1293199
245 1 0 $a Initial events in the muscle atrophy program.
300 $a 302 p.
500 $a Adviser: Priscilla M. Clarkson.
500 $a Source: Dissertation Abstracts International, Volume: 67-04, Section: B, page: 1771.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2006.
520 $a The aim of this dissertation was to explore alterations in human skeletal muscle during a controlled period of immobilization and following spinal cord injury (SCI). Study I examined the effects of an imposed period of immobilization of the adductor pollicis (AP) muscle on muscle function and volume in young (18-25 years) and aged (60-75 years) men. Muscle strength and volume of the AP was assessed before and after immobilization. Results from Study I show that although the older and younger adults had disparate losses in muscle volume they experienced similar losses in muscle strength. These results confirm that even short periods of inactivity promote more rapid losses in muscle volume in older adults, while the ability to generate force is maintained.
520 $a Study II and Study III of this dissertation explored the molecular alterations in human skeletal muscle in response to immobilization or SCI. Muscle biopsies were analyzed at both the transcriptional (microarray analysis, quantitative Real-Time Polymerase Chain Reaction (qRT-PCR)) and translational (Western blotting, Immunohistochemistry (IHC)) level. In Study II, the knee joint of five young men (aged 18-25 years) was immobilized, and muscle biopsies were performed before and after 48h of leg immobilization. Immobilization resulted in increased expression of genes involved in the ubiquitin proteasome pathway and metallothionein function, but no change in respective protein products. However, results of Study II also showed a decrease in gene expression and protein products for the collagens, which are involved in extracellular matrix (ECM) integrity, indicating that disruption to the ECM is an initial step in the muscle atrophy program following immobilization.
520 $a In Study III, analysis of muscle biopsies taken two and five days post-SCI, compared to healthy controls, showed increased gene expression for genes that encode components of the ubiquitin proteasome pathway, metallothioneins, and secretory leukocyte protease inhibitors. Western blotting and IHC showed that protein products for components of the proteolytic core and the metallothioneins increased by five days post-SCI, and protein products were localized to the ECM. These results indicate that components of the ECM are initial targets of proteolytic activity within the first days following SCI.
590 $a School code: 0118.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
690 $a 0382
690 $a 0410
690 $a 0433
710 2 0 $a University of Massachusetts Amherst. $3 1019433
773 0 $t Dissertation Abstracts International $g 67-04B.
790 $a 0118
790 1 0 $a Clarkson, Priscilla M., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3215767