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Effects of creatine feedings on prot...

Ziegenfuss, Timothy Nathan.

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Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power./
Author:	Ziegenfuss, Timothy Nathan.
Description:	100 p.
Notes:	Director: Peter W. R. Lemon.
Contained By:	Dissertation Abstracts International57-09B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9706632
ISBN:	9780591137606

Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power.
Ziegenfuss, Timothy Nathan.

Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power. - 100 p.

Director: Peter W. R. Lemon.

Thesis (Ph.D.)--Kent State University, 1996.

While it is well established creatine plays a central role in the regulation of energy metabolism, studies examining the exercise performance effects of oral creatine feedings in humans have yielded mixed results. Equally interesting, despite compelling in vitro evidence that creatine may act as an anabolic substance, corroborative in vivo investigations are absent from the literature. This series of experiments was designed to examine the effects of creatine supplementation on protein turnover (using ($\sp{15}

ISBN: 9780591137606Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power.
LDR:03170nam 2200289 a 45 001 969120
005 20110920
008 110921s1996 eng d
020 $a 9780591137606
035 $a (UMI)AAI9706632
035 $a AAI9706632
040 $a UMI $c UMI
100 1 $a Ziegenfuss, Timothy Nathan. $3 1293176
245 1 0 $a Effects of creatine feedings on protein turnover, skeletal muscle morphology, cellular hydration, and anaerobic power.
300 $a 100 p.
500 $a Director: Peter W. R. Lemon.
500 $a Source: Dissertation Abstracts International, Volume: 57-09, Section: B, page: 5429.
502 $a Thesis (Ph.D.)--Kent State University, 1996.
520 $a While it is well established creatine plays a central role in the regulation of energy metabolism, studies examining the exercise performance effects of oral creatine feedings in humans have yielded mixed results. Equally interesting, despite compelling in vitro evidence that creatine may act as an anabolic substance, corroborative in vivo investigations are absent from the literature. This series of experiments was designed to examine the effects of creatine supplementation on protein turnover (using ($\sp{15} $n ) glycine) in experienced weight trainers (N = 3), skeletal muscle morphology (using magnetic resonance imaging) and anaerobic exercise performance (using repeated cycle sprints) in high power male (n = 10) and female (n = 10) athletes, and fluid shifts (using multifrequency bioimpedance) in aerobic and cross trained males (N = 10). Following pre-testing and random group assignment, subjects ingested 0.35 g $\cdot$ kg$\sp{-1}$ FFM $\cdot$ d$\sp{-1}$ of creatine monohydrate (Cr) or maltodextrin (P) for three days prior to post-testing (a five day period was used in the ($\sp{15} $n ) glycine study). Collectively, the results suggest acute Cr supplementation: (1) improves cycle sprint performance, (2) increases thigh muscle volume, perhaps by increasing intracellular water, and (3) may improve net (protein synthesis - protein breakdown) protein status. Specifically, statistically significant (p $<$ 0.10) increases were noted in total work during the first, and peak power during the last five of six (10-s) sprints. In addition, a 6.6% increase in skeletal muscle volume of the mid thigh was found in five of six Cr subjects (p $<$ 0.05). Multifrequency bioimpedance data suggested Cr increased total body and intracellular water by 2-3% (p $<$ 0.05). Preliminary protein metabolism data suggest Cr may improve net protein status by increasing protein synthesis and/or decreasing protein breakdown. Within the framework of these and previous experiments, it appears acute Cr ingestion can positively influence several factors related to skeletal muscle hypertrophy and the performance of repeated, explosive exercise. These effects occur regardless of sex, mode of training, or level of fitness.
590 $a School code: 0101.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Education, Physical. $3 1018000
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0433
690 $a 0523
690 $a 0570
710 2 0 $a Kent State University. $3 1017419
773 0 $t Dissertation Abstracts International $g 57-09B.
790 $a 0101
790 1 0 $a Lemon, Peter W. R., $e advisor
791 $a Ph.D.
792 $a 1996
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9706632