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Effects of anthocyanin rich extracts...

Lala, Geeta.

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Effects of anthocyanin rich extracts on multiple biomarkers of colon cancer.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effects of anthocyanin rich extracts on multiple biomarkers of colon cancer./
作者:	Lala, Geeta.
面頁冊數:	93 p.
附註:	Director: Bernadene A. Magnuson.
Contained By:	Masters Abstracts International44-04.
標題:	Agriculture, Food Science and Technology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1431556
ISBN:	9780542475986

Effects of anthocyanin rich extracts on multiple biomarkers of colon cancer.
Lala, Geeta.

Effects of anthocyanin rich extracts on multiple biomarkers of colon cancer. - 93 p.

Director: Bernadene A. Magnuson.

Thesis (M.S.)--University of Maryland, College Park, 2005.

The aim of this study was to investigate the chemoprotective activity of anthocyanin-rich extracts (AREs) from bilberry (Vaccinium myrtillus), chokeberry (Aronia meloncarpa) and grape (Vitis vinifera) by assessing multiple biomarkers of colon cancer in rats treated with a colon carcinogen, azoxymethane. Male F344 rats (n = 40) were fed AIN-93 diet (control) or AIN-93 diet supplemented with AREs for 14 weeks. Biomarkers evaluated included total aberrant crypt foci (ACF) that were reduced in ARE diet groups as compared to the control group. The number of large ACF and colonic cellular proliferation were decreased in rats fed bilberry and chokeberry ARE diets. Rats fed bilberry and grape ARE diets had lower COX-2 mRNA levels expression. Increased levels of fecal anthocyanins, fecal mass and moisture occurred in ARE-fed rats. Significant reduction of fecal bile acids was observed in ARE-fed rats. The results from this study suggest a protective role of AREs in colon carcinogenesis, and indicate multiple mechanisms of action are involved.

ISBN: 9780542475986Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Effects of anthocyanin rich extracts on multiple biomarkers of colon cancer.
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502 $a Thesis (M.S.)--University of Maryland, College Park, 2005.
520 $a The aim of this study was to investigate the chemoprotective activity of anthocyanin-rich extracts (AREs) from bilberry (Vaccinium myrtillus), chokeberry (Aronia meloncarpa) and grape (Vitis vinifera) by assessing multiple biomarkers of colon cancer in rats treated with a colon carcinogen, azoxymethane. Male F344 rats (n = 40) were fed AIN-93 diet (control) or AIN-93 diet supplemented with AREs for 14 weeks. Biomarkers evaluated included total aberrant crypt foci (ACF) that were reduced in ARE diet groups as compared to the control group. The number of large ACF and colonic cellular proliferation were decreased in rats fed bilberry and chokeberry ARE diets. Rats fed bilberry and grape ARE diets had lower COX-2 mRNA levels expression. Increased levels of fecal anthocyanins, fecal mass and moisture occurred in ARE-fed rats. Significant reduction of fecal bile acids was observed in ARE-fed rats. The results from this study suggest a protective role of AREs in colon carcinogenesis, and indicate multiple mechanisms of action are involved.
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