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Metal nanoparticle synthesis and cyt...

Bakhtina, Asya V.

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Metal nanoparticle synthesis and cytotoxicity.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Metal nanoparticle synthesis and cytotoxicity./
Author:	Bakhtina, Asya V.
Description:	108 p.
Notes:	Adviser: Kalle Levon.
Contained By:	Dissertation Abstracts International68-04B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260793

Metal nanoparticle synthesis and cytotoxicity.
Bakhtina, Asya V.

Metal nanoparticle synthesis and cytotoxicity. - 108 p.

Adviser: Kalle Levon.

Thesis (Ph.D.)--Polytechnic University, 2007.

Interest in nanotechnology has been increasing over last decade, nanoscale materials already found their way into number of consumer products and there is even greater potential benefit anticipated in wide range of industrial and biomedical applications.Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Metal nanoparticle synthesis and cytotoxicity.
LDR:02239nam 2200265 a 45 001 967778
005 20110915
008 110915s2007 eng d
035 $a (UMI)AAI3260793
035 $a AAI3260793
040 $a UMI $c UMI
100 1 $a Bakhtina, Asya V. $3 1291650
245 1 0 $a Metal nanoparticle synthesis and cytotoxicity.
300 $a 108 p.
500 $a Adviser: Kalle Levon.
500 $a Source: Dissertation Abstracts International, Volume: 68-04, Section: B, page: 2351.
502 $a Thesis (Ph.D.)--Polytechnic University, 2007.
520 $a Interest in nanotechnology has been increasing over last decade, nanoscale materials already found their way into number of consumer products and there is even greater potential benefit anticipated in wide range of industrial and biomedical applications.
520 $a Yet there is still not enough information about possible harmful effects of such materials on human wellbeing. The effects of metal nanoparticles on human cell culture were investigated in the research presented here. For this purpose syntheses of water soluble gold, silver and palladium nanoparticles as well as their characterization were performed. Silver and palladium nanoparticle samples were found to aggregate which made them undesirable for cytotoxicity studies. Therefore, only gold nanoparticles were used in the cell culture experiments. Adult human dermal fibroblasts were studied in terms of cells morphology, proliferation rates and actin cytoskeleton organization after exposure to gold nanoparticles of two different sizes. Based on the results acquired, it can be concluded that citrate stabilized gold nanoparticles have an adverse effect on adult human dermal fibroblasts. In particular, a significant reduction of the cell area, a sharp decrease of the proliferation rate and a decline of actin fiber density in the cells were observed. It was also concluded that the nanoparticle size plays a major role: larger nanoparticles were found to be more toxic.
590 $a School code: 0179.
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0488
710 2 0 $a Polytechnic University. $3 1249856
773 0 $t Dissertation Abstracts International $g 68-04B.
790 $a 0179
790 1 0 $a Levon, Kalle, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3260793