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Cytotoxicity of metals in welding fu...

Pascal, Laura E.

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Cytotoxicity of metals in welding fumes as a factor in occupational lung disease.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Cytotoxicity of metals in welding fumes as a factor in occupational lung disease./
Author:	Pascal, Laura E.
Description:	117 p.
Notes:	Chairperson: Daniel M. Tessier.
Contained By:	Dissertation Abstracts International64-11B.
Subject:	Health Sciences, Occupational Health and Safety. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3111434
ISBN:	9780496589647

Cytotoxicity of metals in welding fumes as a factor in occupational lung disease.
Pascal, Laura E.

Cytotoxicity of metals in welding fumes as a factor in occupational lung disease. - 117 p.

Chairperson: Daniel M. Tessier.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2003.

Condensed vapors of metals are associated by epidemiological studies with an increased risk for developing occupational lung disease due to welding activities. Chromium, nickel and manganese are predominant metals in welding fumes. In this study, chromium(VI) and manganese, but not nickel, are cytotoxic to normal human lung epithelial cells in vitro (SAEC and BEAS-2B), at concentration ranges correlated to concentrations of these metals found in welding fumes. Chromium(VI) and manganese (0.2--200 muM) caused 64% and 60% loss of cell viability, respectively, following 24 hrs exposure. The toxic effect was associated with increased levels of intracellular phosphoprotein and subsequent release of inflammatory cytokines IL-6 and IL-8, while no release of TNF-alpha, GM-CSF or IL-1beta was observed. Changes in phosphoprotein levels and cytokine release were apparent within I hour following metal treatment. IL-6 and IL-8 are released from lung epithelium to recruit cells of the immune system to sites of tissue damage, manifesting in an inflammatory response and the initiation of repair mechanisms. Therefore, the observed effects of chromium(VI) and manganese in lung epithelial cells demonstrate a mechanism through which the toxicity of these metals can result in signaling to the immune system. This illustrates a potential connection between epithelial intoxication and manifestations of respiratory disease.

ISBN: 9780496589647Subjects--Topical Terms:

1017799
Health Sciences, Occupational Health and Safety.

Cytotoxicity of metals in welding fumes as a factor in occupational lung disease.
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005 20110915
008 110915s2003 eng d
020 $a 9780496589647
035 $a (UMI)AAI3111434
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040 $a UMI $c UMI
100 1 $a Pascal, Laura E. $3 1291638
245 1 0 $a Cytotoxicity of metals in welding fumes as a factor in occupational lung disease.
300 $a 117 p.
500 $a Chairperson: Daniel M. Tessier.
500 $a Source: Dissertation Abstracts International, Volume: 64-11, Section: B, page: 5487.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2003.
520 $a Condensed vapors of metals are associated by epidemiological studies with an increased risk for developing occupational lung disease due to welding activities. Chromium, nickel and manganese are predominant metals in welding fumes. In this study, chromium(VI) and manganese, but not nickel, are cytotoxic to normal human lung epithelial cells in vitro (SAEC and BEAS-2B), at concentration ranges correlated to concentrations of these metals found in welding fumes. Chromium(VI) and manganese (0.2--200 muM) caused 64% and 60% loss of cell viability, respectively, following 24 hrs exposure. The toxic effect was associated with increased levels of intracellular phosphoprotein and subsequent release of inflammatory cytokines IL-6 and IL-8, while no release of TNF-alpha, GM-CSF or IL-1beta was observed. Changes in phosphoprotein levels and cytokine release were apparent within I hour following metal treatment. IL-6 and IL-8 are released from lung epithelium to recruit cells of the immune system to sites of tissue damage, manifesting in an inflammatory response and the initiation of repair mechanisms. Therefore, the observed effects of chromium(VI) and manganese in lung epithelial cells demonstrate a mechanism through which the toxicity of these metals can result in signaling to the immune system. This illustrates a potential connection between epithelial intoxication and manifestations of respiratory disease.
590 $a School code: 0806.
650 4 $a Health Sciences, Occupational Health and Safety. $3 1017799
650 4 $a Health Sciences, Toxicology. $3 1017752
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710 2 0 $a University of Illinois at Chicago, Health Sciences Center. $3 1021703
773 0 $t Dissertation Abstracts International $g 64-11B.
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790 1 0 $a Tessier, Daniel M., $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3111434